Title:
IL-6に対する抗体およびその使用
Document Type and Number:
Japanese Patent JP2012509874
Kind Code:
A
Abstract:
The present invention is directed to therapeutic methods using IL-6 antagonists such as an Abl antibody or antibody fragment having binding specificity for IL-6 to prevent or treat disease or to improve survivability or quality of life of a patient in need thereof. In preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level, reduced serum albumin level, elevated D-dimer or other coagulation cascade related protein(s), cachexia, fever, weakness and/or fatigue prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, and others.
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Inventors:
Garcia, Martinez, Leon
Jensen, Anne Elizabeth Carvalho
Olson, Katie
Duzer, Ben
Latham, John
Kovacevich, Brian
Smith, Jeffrey T. El.
Litton, mark
Schatzman, Randall
Jensen, Anne Elizabeth Carvalho
Olson, Katie
Duzer, Ben
Latham, John
Kovacevich, Brian
Smith, Jeffrey T. El.
Litton, mark
Schatzman, Randall
Application Number:
JP2011537437A
Publication Date:
April 26, 2012
Filing Date:
November 24, 2009
Export Citation:
Assignee:
Alder By Offer Mousticals, Inc.
International Classes:
A61K39/395; A61K31/7088; A61K35/76; A61K45/00; A61K48/00; A61P3/00; A61P3/02; A61P7/00; A61P29/00; A61P31/12; A61P35/00; A61P37/02; A61P37/06; G01N33/58; A61K39/00; C07K16/24; C12N15/09
Domestic Patent References:
| JP2007528691A | 2007-10-18 | |||
| JP2008538931A | 2008-11-13 | |||
| JP2005535341A | 2005-11-24 |
Other References:
JPN6013061498; Ｐｏｐｋｏｖ，Ｍ．，ｅｔ ａｌ．: '"Ｒａｂｂｉｔ Ｉｍｍｕｎｅ Ｒｅｐｅｒｔｏｉｒｅｓ ａｓ Ｓｏｕｒｃｅｓ ｆｏｒ Ｔｈｅｒａｐｅｕｔｉｃ Ｍｏｎｏｃｌｏｎａｌ Ａｎｔｉｂｏｄｉｅｓ： Ｔｈｅ Ｉｍｐａｃｔ ｏｆ Ｋａｐｐａ Ａｌ' Ｊ． Ｍｏｌ． Ｂｉｏｌ． Ｖｏｌ．３２５，Ｎｏ．２, 20030110, Ｐ．３２５-３３５
Attorney, Agent or Firm:
Asamura patent office
Hideto Asamura
Hajime Asamura
Kanamori Koji
Naganuma Akio
Yukihiro Ikeda
Kajiwara Saiko
Shinmura Morio
Yuko Nagase
Youichi Inoue
Mari Yuge
Yoshitaka Watanabe
Katsuhiko Shimomura
Shinichi Inoue
Hideto Asamura
Hajime Asamura
Kanamori Koji
Naganuma Akio
Yukihiro Ikeda
Kajiwara Saiko
Shinmura Morio
Yuko Nagase
Youichi Inoue
Mari Yuge
Yoshitaka Watanabe
Katsuhiko Shimomura
Shinichi Inoue