Title:
6-シクロアミノ-3-(1H-ピロロ[2,3-b]ピリジン-4-イル)イミダゾ[1,2-b]ピリダジン誘導体、この調製およびこの治療的使用
Document Type and Number:
Japanese Patent JP2012510453
Kind Code:
A
Abstract:
The invention relates to 6-cycloamino-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazine derivatives corresponding to the general formula (I) in which R2 represents an aryl group optionally substituted with one or more halogen atoms or C1-6-alkyl, C1-6-alkyloxy, C1-6-alkylthio, C1-6-fluoroalkyl, C1-6-fluoroalkyloxy and -CN groups or R2 represents a group chosen from C1-6-alkyl, C1-6-fluoroalkyl, C3-7-cycloalkyl or C3-7-cycloalkyl-C1-6-alkyl groups; A represents a C1-7-alkylene group; B represents a C1-7-alkylene group; L represents either a nitrogen atom optionally substituted with an Rc or Rd group, or a carbon atom substituted with an Re1 group and an Rd group or two Re2 groups; the carbon atoms of A and of B being optionally substituted with one or more Rf groups, which may be identical to or different from one another. Preparation process and therapeutic use.
Inventors:
Paco, Christoph
Pieuek, Frederik
Pieuek, Frederik
Application Number:
JP2011538042A
Publication Date:
May 10, 2012
Filing Date:
November 30, 2009
Export Citation:
Assignee:
SANOFI
International Classes:
C07D519/00; A61K31/5025; A61P9/10; A61P19/02; A61P25/00; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/32; A61P25/34; A61P25/36; A61P29/00; A61P35/00; A61P35/02; A61P43/00
Domestic Patent References:
| JP5431319B2 | 2014-03-05 | |||
| JP5537424B2 | 2014-07-02 | |||
| JP2010531342A | 2010-09-24 |
Foreign References:
| WO2008079880A1 | 2008-07-03 | |||
| WO2008138834A1 | 2008-11-20 | |||
| WO2008138889A2 | 2008-11-20 | |||
| WO2007025540A2 | 2007-03-08 | |||
| WO2008141065A1 | 2008-11-20 |
Attorney, Agent or Firm:
Kawaguchi International Patent Office