Title:
膵がんの治療
Document Type and Number:
Japanese Patent JP2012510489
Kind Code:
A
Abstract:
A composition for use in the treatment of a pancreatic tumour or cyst comprising microspheres which comprise a water insoluble, water-swellable polymer and a chemotherapeutic agent; wherein the microspheres, when equilibrated in water at 37°C, comprise at least 40 wt% water based on weight of polymer plus water, wherein the polymer is anionically charged at pH7 and the chemotherapeutic agent is cationically charged and electrostatically associated with the polymer, and wherein the composition further comprises a viscosity modifier.
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Inventors:
Lewis, Andrew, Leonard
Stratford, Peter, William
Foster, richard, edward, john
Stratford, Peter, William
Foster, richard, edward, john
Application Number:
JP2011538957A
Publication Date:
May 10, 2012
Filing Date:
November 25, 2009
Export Citation:
Assignee:
Bio Compatibles U.K. Limited
International Classes:
A61K45/00; A61K31/136; A61K31/4745; A61K31/704; A61K47/32; A61K47/36; A61K47/48; A61P1/18; A61P35/00; A61P43/00
Domestic Patent References:
| JP2008512370A | 2008-04-24 | |||
| JP2006515358A | 2006-05-25 |
Foreign References:
| WO2007090897A1 | 2007-08-16 | |||
| WO2008128580A1 | 2008-10-30 |
Other References:
JPN6013012094; Ｃｌｉｎｉｃａｌ Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ Ｖｏｌ．１１，Ｎｏ．４, 2005, ｐ１６５０-１６５７
JPN6013012095; 膵臓 Ｖｏｌ．２２，Ｎｏ．１, 2007, ｐ５２-５６
JPN6013012096; 癌と化学療法 Ｖｏｌ．２３，Ｎｏ．１２, 1996, ｐ１６４７-１６５０
JPN6013012097; Ｃａｎｃｅｒ Ｂｉｏｌｏｇｙ ａｎｄ Ｔｈｅｒａｐｙ Ｖｏｌ．７，Ｎｏ．４, 200804, ｐ５９６-６０１
JPN6013012099; 胆と膵 Ｖｏｌ．２９，Ｎｏ．５, 200805, ｐ４３３-４３８
JPN6013012100; Ｇａｓｔｒｏｉｎｔｅｓｔｉｎａｌ Ｅｎｄｏｓｃｏｐｙ Ｖｏｌ．６５，Ｎｏ．３, 2007, ｐ４４８-４５３
JPN6013012102; Ｅｎｄｏｓｃｏｐｙ Ｖｏｌ．３９，Ｎｏ．６, 2007, ｐ５３０-５３４
JPN6013012104; 日本消化器病学会雑誌 Ｖｏｌ．８４，Ｎｏ．９, 1987, ｐ１８１３-１８２０
JPN6013012105; 日本癌学会総会記事 Ｖｏｌ．６２, 2003, ｐ５５１
JPN6013012107; ＩＵＢＭＢ Ｌｉｆｅ Ｖｏｌ．５９，Ｎｏ．１１, 2007, ｐ７１７-７２１
JPN6013012109; 日本消化器外科学会雑誌 Ｖｏｌ．３９，Ｎｏ．７, 2006, ｐ１３０５
JPN6013012095; 膵臓 Ｖｏｌ．２２，Ｎｏ．１, 2007, ｐ５２-５６
JPN6013012096; 癌と化学療法 Ｖｏｌ．２３，Ｎｏ．１２, 1996, ｐ１６４７-１６５０
JPN6013012097; Ｃａｎｃｅｒ Ｂｉｏｌｏｇｙ ａｎｄ Ｔｈｅｒａｐｙ Ｖｏｌ．７，Ｎｏ．４, 200804, ｐ５９６-６０１
JPN6013012099; 胆と膵 Ｖｏｌ．２９，Ｎｏ．５, 200805, ｐ４３３-４３８
JPN6013012100; Ｇａｓｔｒｏｉｎｔｅｓｔｉｎａｌ Ｅｎｄｏｓｃｏｐｙ Ｖｏｌ．６５，Ｎｏ．３, 2007, ｐ４４８-４５３
JPN6013012102; Ｅｎｄｏｓｃｏｐｙ Ｖｏｌ．３９，Ｎｏ．６, 2007, ｐ５３０-５３４
JPN6013012104; 日本消化器病学会雑誌 Ｖｏｌ．８４，Ｎｏ．９, 1987, ｐ１８１３-１８２０
JPN6013012105; 日本癌学会総会記事 Ｖｏｌ．６２, 2003, ｐ５５１
JPN6013012107; ＩＵＢＭＢ Ｌｉｆｅ Ｖｏｌ．５９，Ｎｏ．１１, 2007, ｐ７１７-７２１
JPN6013012109; 日本消化器外科学会雑誌 Ｖｏｌ．３９，Ｎｏ．７, 2006, ｐ１３０５
Attorney, Agent or Firm:
Isshiki International Patent Service Corporation