Title:
新規CC-1065類似体およびその複合体
Document Type and Number:
Japanese Patent JP2012513954
Kind Code:
A
Abstract:
This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.
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Inventors:
Beuskel, Patrick Henry
Koumans, Rudy Geraldus Elizabeth
Ergel Suma, Ronald Kristian
Menge, Willo Michael Petrus Bernardus
Josten, Johannes Albertus Frederiks
Speakel, Henry Johannes
De Grote, Frances Marinus Hendrix
Koumans, Rudy Geraldus Elizabeth
Ergel Suma, Ronald Kristian
Menge, Willo Michael Petrus Bernardus
Josten, Johannes Albertus Frederiks
Speakel, Henry Johannes
De Grote, Frances Marinus Hendrix
Application Number:
JP2011535528A
Publication Date:
June 21, 2012
Filing Date:
November 03, 2009
Export Citation:
Assignee:
Cintaluga Beevy
International Classes:
C07D209/60; A61K31/403; A61K31/404; A61K31/407; A61K31/4184; A61K31/4192; A61K31/423; A61K31/428; A61K31/4365; A61K31/437; A61K39/395; A61K47/48; A61P29/00; A61P31/00; A61P31/04; A61P31/12; A61P35/00; A61P37/00; C07D209/62; C07D403/06; C07D403/14; C07D413/06; C07D417/06; C07D471/04; C07D491/048; C07D491/056; C07D495/04
Domestic Patent References:
| JP2000511893A | 2000-09-12 | |||
| JP2005532287A | 2005-10-27 | |||
| JP2000511893A | 2000-09-12 | |||
| JP2005532287A | 2005-10-27 |
Foreign References:
| WO2002096910A1 | 2002-12-05 | |||
| WO2007089149A2 | 2007-08-09 | |||
| WO2007051081A1 | 2007-05-03 | |||
| EP0702014A1 | 1996-03-20 | |||
| EP0656360A1 | 1995-06-07 | |||
| EP0359454A1 | 1990-03-21 | |||
| EP0154445A1 | 1985-09-11 | |||
| WO2002096910A1 | 2002-12-05 | |||
| WO2007089149A2 | 2007-08-09 | |||
| WO2007051081A1 | 2007-05-03 | |||
| EP0702014A1 | 1996-03-20 | |||
| EP0656360A1 | 1995-06-07 | |||
| EP0359454A1 | 1990-03-21 | |||
| EP0154445A1 | 1985-09-11 |
Attorney, Agent or Firm:
Kurata Masatoshi
Takakura Shigeo
Satoshi Kono
Makoto Nakamura
Yoshihiro Fukuhara
Takashi Mine
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Kocho Chojiro
Naoki Kono
Katsu Sunagawa
Morisezo Iseki
Tatsushi Sato
Takashi Okada
Mihoko Horiuchi
Takenori Masanori
Takakura Shigeo
Satoshi Kono
Makoto Nakamura
Yoshihiro Fukuhara
Takashi Mine
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Kocho Chojiro
Naoki Kono
Katsu Sunagawa
Morisezo Iseki
Tatsushi Sato
Takashi Okada
Mihoko Horiuchi
Takenori Masanori