Title:
5-HT受容体調節物質およびその使用方法
Document Type and Number:
Japanese Patent JP2012524797
Kind Code:
A
Abstract:
The present application relates to 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2- a ][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2- a ][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1 H- pyrido[3,4- d ][2]benzazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2- a ][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7 H- pyrazino[1,2- a ][4,1]henzoxazepine, and 2,3,4,4a,5,6-hexahydro-1 H- pyrazino[2,1- d ][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2- d ]pyrido[3,2-b][1,4]diazepine derivatives of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X 1 , X 2 , X 3 X 4 , Y 1 , Y 2 , and Y 3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
Inventors:
One, Inn
Briewer, The Eason Tay
Akrit Pourou-Zanze, Irini
Deeuritsk, Staban Davryu
Pauluki, Frauke
Braille, Billfleet
Relo, Anna-Lucia
Briewer, The Eason Tay
Akrit Pourou-Zanze, Irini
Deeuritsk, Staban Davryu
Pauluki, Frauke
Braille, Billfleet
Relo, Anna-Lucia
Application Number:
JP2012507366A
Publication Date:
October 18, 2012
Filing Date:
April 22, 2010
Export Citation:
Assignee:
ABBOTT LABORATORIES
International Classes:
C07D471/04; A61K31/55; A61K31/551; A61K31/5513; A61K31/553; A61P1/04; A61P1/14; A61P3/04; A61P3/10; A61P13/02; A61P15/10; A61P17/06; A61P25/00; A61P25/06; A61P25/10; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/34; A61P27/02; A61P43/00; C07D487/04; C07D487/14; C07D498/04
Foreign References:
| WO2008007661A1 | 2008-01-17 | |||
| WO1988007997A1 | 1988-10-20 | |||
| EP0206225A2 | 1986-12-30 | |||
| US20080188460A1 | 2008-08-07 | |||
| EP0463691A2 | 1992-01-02 | |||
| WO2008007661A1 | 2008-01-17 | |||
| WO1988007997A1 | 1988-10-20 | |||
| EP0206225A2 | 1986-12-30 |
Other References:
JPN5012013090; ＢＨＡＮＤＡＲＩ Ｋ ｅｔ ａｌ．: 'ＡＧＥＮＴＳ ＡＣＴＩＮＧ ＯＮ ＣＥＮＴＲＡＬ ＮＥＲＶＯＵＳ ＳＹＳＴＥＭ．： ＰＡＲＴ ＸＸＸＩＶ-１，２，３，４，４Ａ，５，６，７-以下備考' ＩＮＤＩＡＮ ＪＯＵＲＮＡＬ ＯＦ ＣＨＥＭＩＳＴＲＹ，ＳＥＣＴＩＯＮ Ｂ Ｖｏｌ．２５Ｂ， Ｎｏ．１２, 1986, Ｐｐ．１２３１-３
JPN5012013094; ＳＭＩＴＨ Ｒ．Ｇ． ｅｔ ａｌ．: 'ＳＹＮＴＨＥＳＩＳ ＡＮＤ ＡＮＸＩＯＬＹＴＩＣ ＡＣＴＩＶＩＴＹ ＯＦ Ａ ＳＥＲＩＥＳ ＯＦ ＰＹＲＡＺＩＮＯ［１，２-Ａ］［１，４］ ＢＥＮＺＯＤＩＡＺＥＰＩＮＥ ＤＥＲＩＶＡＴＩＶＥＳ' ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．２３，Ｎｏ．８, 1980, ｐ．９５２-５
JPN5012013088; ＲＵＳＳＥＬＬ Ｍ．Ｇ．Ｎ． ｅｔ ａｌ．: 'ＢＥＮＺ［Ｆ］ＩＳＯＱＵＩＮＯＬＩＮＥ ＡＮＡＬＯＧＵＥＳ ＡＳ ＨＩＧＨ-ＡＦＦＩＮＩＴＹ ＳＩＧＭＡ ＬＩＧＡＮＤＳ' ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．３５， Ｎｏ．１１, 1992, ｐ．２０２５-３３
JPN5012013093; ＭＵＥＬＬＥＲ Ｗ． ｅｔ ａｌ．: 'ＳＥＶＥＮ-ＭＥＭＢＥＲＥＤ ＨＥＴＥＲＯＣＹＣＬＩＣＳ．ＰＡＲＴ ２９． ＳＹＮＴＨＥＳＩＳ ＯＦ １，２-ＡＮＮＥＬＡＴＥＤ １，４-ＢＥＮＺＯＤＩＡＺＥＰＩＮＥＳ 以下備考' ＨＥＬＶＥＴＩＣＡ ＣＨＩＭＩＣＡ ＡＣＴＡ Ｖｏｌ．６５，Ｎｏ．７, 1982, ｐ．２１１８-３２
JPN5012013090; ＢＨＡＮＤＡＲＩ Ｋ ｅｔ ａｌ．: 'ＡＧＥＮＴＳ ＡＣＴＩＮＧ ＯＮ ＣＥＮＴＲＡＬ ＮＥＲＶＯＵＳ ＳＹＳＴＥＭ．： ＰＡＲＴ ＸＸＸＩＶ-１，２，３，４，４Ａ，５，６，７-以下備考' ＩＮＤＩＡＮ ＪＯＵＲＮＡＬ ＯＦ ＣＨＥＭＩＳＴＲＹ，ＳＥＣＴＩＯＮ Ｂ Ｖｏｌ．２５Ｂ， Ｎｏ．１２, 1986, Ｐｐ．１２３１-３
JPN5012013094; ＳＭＩＴＨ Ｒ．Ｇ． ｅｔ ａｌ．: 'ＳＹＮＴＨＥＳＩＳ ＡＮＤ ＡＮＸＩＯＬＹＴＩＣ ＡＣＴＩＶＩＴＹ ＯＦ Ａ ＳＥＲＩＥＳ ＯＦ ＰＹＲＡＺＩＮＯ［１，２-Ａ］［１，４］ ＢＥＮＺＯＤＩＡＺＥＰＩＮＥ ＤＥＲＩＶＡＴＩＶＥＳ' ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．２３，Ｎｏ．８, 1980, ｐ．９５２-５
JPN5012013094; ＳＭＩＴＨ Ｒ．Ｇ． ｅｔ ａｌ．: 'ＳＹＮＴＨＥＳＩＳ ＡＮＤ ＡＮＸＩＯＬＹＴＩＣ ＡＣＴＩＶＩＴＹ ＯＦ Ａ ＳＥＲＩＥＳ ＯＦ ＰＹＲＡＺＩＮＯ［１，２-Ａ］［１，４］ ＢＥＮＺＯＤＩＡＺＥＰＩＮＥ ＤＥＲＩＶＡＴＩＶＥＳ' ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．２３，Ｎｏ．８, 1980, ｐ．９５２-５
JPN5012013088; ＲＵＳＳＥＬＬ Ｍ．Ｇ．Ｎ． ｅｔ ａｌ．: 'ＢＥＮＺ［Ｆ］ＩＳＯＱＵＩＮＯＬＩＮＥ ＡＮＡＬＯＧＵＥＳ ＡＳ ＨＩＧＨ-ＡＦＦＩＮＩＴＹ ＳＩＧＭＡ ＬＩＧＡＮＤＳ' ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．３５， Ｎｏ．１１, 1992, ｐ．２０２５-３３
JPN5012013093; ＭＵＥＬＬＥＲ Ｗ． ｅｔ ａｌ．: 'ＳＥＶＥＮ-ＭＥＭＢＥＲＥＤ ＨＥＴＥＲＯＣＹＣＬＩＣＳ．ＰＡＲＴ ２９． ＳＹＮＴＨＥＳＩＳ ＯＦ １，２-ＡＮＮＥＬＡＴＥＤ １，４-ＢＥＮＺＯＤＩＡＺＥＰＩＮＥＳ 以下備考' ＨＥＬＶＥＴＩＣＡ ＣＨＩＭＩＣＡ ＡＣＴＡ Ｖｏｌ．６５，Ｎｏ．７, 1982, ｐ．２１１８-３２
JPN5012013090; ＢＨＡＮＤＡＲＩ Ｋ ｅｔ ａｌ．: 'ＡＧＥＮＴＳ ＡＣＴＩＮＧ ＯＮ ＣＥＮＴＲＡＬ ＮＥＲＶＯＵＳ ＳＹＳＴＥＭ．： ＰＡＲＴ ＸＸＸＩＶ-１，２，３，４，４Ａ，５，６，７-以下備考' ＩＮＤＩＡＮ ＪＯＵＲＮＡＬ ＯＦ ＣＨＥＭＩＳＴＲＹ，ＳＥＣＴＩＯＮ Ｂ Ｖｏｌ．２５Ｂ， Ｎｏ．１２, 1986, Ｐｐ．１２３１-３
JPN5012013094; ＳＭＩＴＨ Ｒ．Ｇ． ｅｔ ａｌ．: 'ＳＹＮＴＨＥＳＩＳ ＡＮＤ ＡＮＸＩＯＬＹＴＩＣ ＡＣＴＩＶＩＴＹ ＯＦ Ａ ＳＥＲＩＥＳ ＯＦ ＰＹＲＡＺＩＮＯ［１，２-Ａ］［１，４］ ＢＥＮＺＯＤＩＡＺＥＰＩＮＥ ＤＥＲＩＶＡＴＩＶＥＳ' ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．２３，Ｎｏ．８, 1980, ｐ．９５２-５
Attorney, Agent or Firm:
Kawaguchi International Patent Office