Title:
スルホンアミドおよびアミノ酸の固体形態
Document Type and Number:
Japanese Patent JP2012526128
Kind Code:
A
Abstract:
Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, and forms thereof are active on each of BRaf and c-Raf-1 protein kinase, and may also be active on either or both of A-Raf and B-Raf V600E protein kinase. Also described are methods of use thereof to treat diseases and conditions, including melanoma, colorectal cancer, thyroid cancer, ovarian cancer, and biliary tract cancer.
Inventors:
Gary Connard Weiser
Ibrahim, Prabha, N.
Wayne Spyvak
Cho, Hannah
Si, Song Yuen
Wu, Guoshan
Ibrahim, Prabha, N.
Wayne Spyvak
Cho, Hannah
Si, Song Yuen
Wu, Guoshan
Application Number:
JP2012509907A
Publication Date:
October 25, 2012
Filing Date:
May 04, 2010
Export Citation:
Assignee:
PLEXXIKON INC.
International Classes:
C07D471/04; A61K31/437; A61P35/00; A61P43/00
Domestic Patent References:
| JP2008546797A | 2008-12-25 |
Foreign References:
| WO2009012283A1 | 2009-01-22 | |||
| WO2008079903A1 | 2008-07-03 |
Other References:
JPN6014028679; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ ４２, 2001, ５８５３-５８５６
Attorney, Agent or Firm:
Seiji Ohno
Keiko Kanemoto
Koji Morita
Reiko Tanaka
Yuko Matsuniya
Ken Kitano
Natsuki Ito
Keiko Kanemoto
Koji Morita
Reiko Tanaka
Yuko Matsuniya
Ken Kitano
Natsuki Ito