Title:
膵臓癌細胞または組織に特異的に結合できる核酸アプタマー及びその用途
Document Type and Number:
Japanese Patent JP2012528587
Kind Code:
A
Abstract:
The present invention relates to a nucleic acid aptamer which can specifically recognize and bind to pancreatic cancer cells or tissues. The nucleic acid aptamer can bind specifically only to pancreatic cancer cells or tissues without binding to normal pancreatic cancer tissue, and thus can be effectively used as a composition for diagnosing and treating pancreatic cancer. In addition, the nucleic acid aptamer can detect not only the terminal pancreatic cancer cell line Capan-1, but also the early pancreatic cancer cell line Panc-1, and thus can be used for early diagnosis of pancreatic cancer, thereby contributing to increasing the survival rate of pancreatic cancer patients.
Inventors:
Lee Dong Gi
Puja Dua
Puja Dua
Application Number:
JP2012513867A
Publication Date:
November 15, 2012
Filing Date:
June 01, 2010
Export Citation:
Assignee:
Sung Kyung University Foundation for Corporate Collaboration
International Classes:
C12N15/115; A61K31/7105; A61P1/18; A61P35/00; C12M1/34; C12Q1/02
Domestic Patent References:
| JP2004503214A | 2004-02-05 | |||
| JP2007523631A | 2007-08-23 |
Other References:
JPN6013046902; Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｊｏｕｒｎａｌ ｏｆ Ｍｏｌｅｃｕｌａｒ Ｓｃｉｅｎｃｅｓ ｖｏｌ．９, 2008, ｐ．６６８-６７８
Attorney, Agent or Firm:
Kenichi Morita
Kenjiro Yamaguchi
Kenjiro Yamaguchi