Title:
眼科用用途のための局所薬物送達システム
Document Type and Number:
Japanese Patent JP2012529509
Kind Code:
A
Abstract:
Topical drug delivery systems for ophthalmic use including mixed nanomicellar formulations of water-insoluble drugs and methods of treating diseases affecting the posterior ocular segments are disclosed. In an embodiment, an aqueous ophthalmic solution includes nanomicelles in a physiologically acceptable buffer, having a pH of 5.0 to 8.0, wherein a corticosteroid at a concentration from about 0.01% w/v to about 1.00% w/v is solubilized through entrapment in a mixed micellar hydrophobic core with a corona composed of hydrophilic chains extending from the hydrophobic core, wherein the nanomicelles comprise vitamin E TPGS at a concentration ranging from about 3.0% w/v to about 5.0% w/v stabilized with octoxynol-40 at a concentration ranging from about 1.0% w/v to about 3.0% w/v.
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Inventors:
Asim Kay Mitra
Poonum Earl Varagaleti
Ulrich M. Grau
Poonum Earl Varagaleti
Ulrich M. Grau
Application Number:
JP2012514962A
Publication Date:
November 22, 2012
Filing Date:
May 05, 2010
Export Citation:
Assignee:
LUX BIOSCIENCES, INC.
International Classes:
A61K31/573; A61K9/50; A61K47/34; A61P27/02
Foreign References:
| WO2009048929A1 | 2009-04-16 |
Attorney, Agent or Firm:
Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Sakurai Yoko
Satoshi Hashimoto
Takuji Yamada
Michiko Matsutani
Sakurai Yoko
Satoshi Hashimoto