Title:
JNK阻害剤
Document Type and Number:
Japanese Patent JP2013501746
Kind Code:
A
Abstract:
The invention relates to JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses JNK inhibitors, as described below in Formula I: wherein p, q, Y', r, R1, R2, X, X1, X2, X3, and X4 are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.
Inventors:
Gon, Ray
Han, Xiao Chun
Macula, ferenc
Palmer, Wiley Sorang
Raptova, Rubika
Han, Xiao Chun
Macula, ferenc
Palmer, Wiley Sorang
Raptova, Rubika
Application Number:
JP2012524207A
Publication Date:
January 17, 2013
Filing Date:
August 06, 2010
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
A61K31/506; C07D401/14; A61K45/00; A61P3/10; A61P9/10; A61P11/06; A61P13/12; A61P19/02; A61P25/00; A61P25/16; A61P25/28; A61P29/00; A61P35/00; A61P35/02; A61P43/00; C07D403/04
Domestic Patent References:
| JP2010502668A | 2010-01-28 |
Foreign References:
| US20080146565A1 | 2008-06-19 | |||
| WO2008028860A1 | 2008-03-13 |
Attorney, Agent or Firm:
Patent business corporation Tsukuni
Hajime Tsukuni
Yasuo Yanagibashi
Satoko Ito
Keiko Ozawa
Toshio Miyake
Yasuhiro Oguni
Yoko Tanaka
Atsushi Shiomi
Fusayuki Saito
Hajime Tsukuni
Yasuo Yanagibashi
Satoko Ito
Keiko Ozawa
Toshio Miyake
Yasuhiro Oguni
Yoko Tanaka
Atsushi Shiomi
Fusayuki Saito