放射性ヨウ素化方法 - GE HEALTHCARE LIMITED

Title:

放射性ヨウ素化方法

Document Type and Number:

Japanese Patent JP2013502400

Kind Code:

A

Abstract:

The present invention provides a novel method of labelling biological targeting molecules (BTMs) of interest with radioiodine. Also provided are novel radioiodinated BTMs prepared using the method, as well as radiopharmaceutical compositions comprising such radioiodinated BTMs. The invention also provides radioiodinated intermediates useful in the method, as well as in vivo imaging methods using.

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Inventors:

Michelle Avory
Trigg, William

Application Number:

JP2012525175A

Publication Date:

January 24, 2013

Filing Date:

August 20, 2010

Export Citation:

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Assignee:

GE HEALTHCARE LIMITED

International Classes:

C07D249/04; A61K31/4192; A61K31/42; A61K47/42; A61K47/48; A61K51/00; C07B59/00; C07B61/00; C07K5/09; C07K7/06; C07K7/08; C07K7/52

Domestic Patent References:

JP2008540338A	2008-11-20
JP2008528445A	2008-07-31
JP2008540338A	2008-11-20

Foreign References:

WO2007148089A2

2007-12-27

Other References:

JPN6014038070; ＫＡＢＡＬＫＡ，Ｇ．Ｗ．　ｅｔ　ａｌ．: Ｊｏｕｒｎａｌ　ｏｆ　Ｌａｂｅｌｌｅｄ　Ｃｏｍｐｏｕｎｄｓ　ａｎｄ　ＲａｄｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓＶｏｌ．４８, 2005, ｐ．３５９-６２
JPN6014038071; ＫＡＢＡＬＫＡ，Ｇ．Ｗ．　ｅｔ　ａｌ．: Ｊｏｕｒｎａｌ　ｏｆ　Ｌａｂｅｌｌｅｄ　Ｃｏｍｐｏｕｎｄｓ　ａｎｄ　ＲａｄｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓＶｏｌ．５０, 2007, ｐ．４４６-７
JPN6014038073; Ｓｃｉｅｎｅｃｅ　ｏｆ　Ｓｙｎｔｈｅｓｉｓ , 2006, ｐ．９０４-３２
JPN6014038072; ＫＵ，Ｙ．Ｙ．　ｅｔ　ａｌ．: Ｏｒｇａｎｉｃ　ＬｅｔｔｅｒｓＶｏｌ．３，　Ｎｏ．２６, 2001, ｐ．４１８５-７

Attorney, Agent or Firm:

Arakawa Satoshi
Hirokazu Ogura
Toshihisa Kurokawa

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