Title:
前立腺癌の診断および病期分類のための非侵襲的マーカーとなる血中miRNA
Document Type and Number:
Japanese Patent JP2013509169
Kind Code:
A
Abstract:
The present invention relates to a method for staging prostate cancer in a subject suffering from prostate cancer, said method comprises (a) determining the amount of at least one miRNA selected from the group consisting of miRNA-375, miRNA-141, miRNA-200b, miRNA-516a-3p and miRNA9*, or the amount of a precursor molecule in a sample from said patient and (b) comparing the, thus, determined amount with a reference amount. Moreover, the present invention is concerned with a method for identifying a subject susceptible to prostate cancer therapy and to a method for diagnosing prostate cancer. Further envisaged by the present invention are a kit and a device adapted to carry out the method of the present invention.
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Inventors:
Blase, Jan Christoph
Zultmann, Holger
Kuner, luprecht
Johannes, Marc
Tim Biswald
Maria, felt
Schlom, Torsten
Hese, alexander
Stoiber, Thomas
Zultmann, Holger
Kuner, luprecht
Johannes, Marc
Tim Biswald
Maria, felt
Schlom, Torsten
Hese, alexander
Stoiber, Thomas
Application Number:
JP2012535858A
Publication Date:
March 14, 2013
Filing Date:
October 29, 2010
Export Citation:
Assignee:
Deutsches Krebs Forschungszentrum
Universitate Skrnikum Hamburg-Eppendorf
Universitate Skrnikum Hamburg-Eppendorf
International Classes:
C12Q1/68; G01N33/50; C12N15/09
Foreign References:
| WO2009097136A1 | 2009-08-06 | |||
| WO2010062706A2 | 2010-06-03 | |||
| WO2009108860A2 | 2009-09-03 |
Other References:
JPN6015000190; ＮＡＴＵＲＥ ＣＥＬＬ ＢＩＯＬＯＧＹ Ｖｏｌ． １０， Ｎｏ． ２, 200802, ｐｐ． ２０２-２１０
JPN6015000188; 第６８回日本癌学会学術総会記事 , 20090831, ｐｐ． １４７， Ｐ-０２２３
JPN6015000186; Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ Ｖｏｌ． ６８， Ｎｏ． １５, 20080801, ｐｐ． ６１６２-６１７０
JPN6015000188; 第６８回日本癌学会学術総会記事 , 20090831, ｐｐ． １４７， Ｐ-０２２３
JPN6015000186; Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ Ｖｏｌ． ６８， Ｎｏ． １５, 20080801, ｐｐ． ６１６２-６１７０
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka