Title:
末端置換を含むsiRNA化合物
Document Type and Number:
Japanese Patent JP2013511990
Kind Code:
A
Abstract:
The invention relates to modified siRNA compounds which down-regulate target gene expression, to pharmaceutical compositions comprising such compounds and to methods of treating and/or preventing the incidence or severity of various diseases or conditions associated with the genes and/or symptoms associated with such diseases or conditions.
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Inventors:
Avkin-Nachum Sharon
Application Number:
JP2012541211A
Publication Date:
April 11, 2013
Filing Date:
November 25, 2010
Export Citation:
Assignee:
QUARK PHARMACEUTICALS,INC.
International Classes:
C12N15/09; A61K31/713; A61K48/00; A61P1/02; A61P9/10; A61P11/00; A61P11/16; A61P13/12; A61P17/02; A61P25/00; A61P25/28; A61P27/02; A61P27/06; A61P27/16; A61P35/00; A61P37/06; A61P43/00; C12N15/113
Foreign References:
| WO2005001043A2 | 2005-01-06 | |||
| WO2009044392A2 | 2009-04-09 |
Other References:
JPN6015006126; Ｎｕｃｌｅｉｃ Ａｃｉｄ Ｒｅｓｅａｒｃｈ Ｖｏｌ．３３， Ｎｏ．５, 2005, ｐｐ．１６７１-１６７７
JPN6015006130; Ｎｕｃｌｅｉｃ Ａｃｉｄ Ｒｅｓｅａｒｃｈ Ｖｏｌ．３７， Ｎｏ．２２, 200910, ｐｐ．７５６０-７５６９
JPN6015006115; Ｎａｔｕｒｅ Ｓｔｒｕｃｔｕａｌ ＆ Ｍｏｌｅｃｕｌａｒ Ｂｉｏｌｏｇｙ Ｖｏｌ．１１， Ｎｏ．７, 2004, ｐｐ．５９９-６０６， Ｓｕｐｐｌｅｍｅｎｔａｒｙ Ｆｉｇｕｒｅ
JPN6015006118; バイオテクノロジージャーナル Ｖｏｌ．１-２, 2006, ｐｐ．２３-２８
JPN6015006123; Ｎｕｃｌｅｉｃ Ａｃｉｄｓ Ｒｅｓｅａｒｃｈ Ｖｏｌ．３６， Ｎｏ．７, 2008, ｐｐ．２１３６-２１５１
JPN6015006130; Ｎｕｃｌｅｉｃ Ａｃｉｄ Ｒｅｓｅａｒｃｈ Ｖｏｌ．３７， Ｎｏ．２２, 200910, ｐｐ．７５６０-７５６９
JPN6015006115; Ｎａｔｕｒｅ Ｓｔｒｕｃｔｕａｌ ＆ Ｍｏｌｅｃｕｌａｒ Ｂｉｏｌｏｇｙ Ｖｏｌ．１１， Ｎｏ．７, 2004, ｐｐ．５９９-６０６， Ｓｕｐｐｌｅｍｅｎｔａｒｙ Ｆｉｇｕｒｅ
JPN6015006118; バイオテクノロジージャーナル Ｖｏｌ．１-２, 2006, ｐｐ．２３-２８
JPN6015006123; Ｎｕｃｌｅｉｃ Ａｃｉｄｓ Ｒｅｓｅａｒｃｈ Ｖｏｌ．３６， Ｎｏ．７, 2008, ｐｐ．２１３６-２１５１
Attorney, Agent or Firm:
Masahiro Nanjo
Ayako Seta
Takashi Matsuzaki
Ayako Seta
Takashi Matsuzaki