Title:
GDNFファミリーリガンド(GFL)のミメティックまたはRETシグナル経路活性化因子を用いた、神経系細胞の生存を容易にするための方法
Document Type and Number:
Japanese Patent JP2013513588
Kind Code:
A
Abstract:
Disclosed are compounds and methods for treating neurological and other disorders by administering to a subject in need thereof an effective amount of a compound having binding and/or modulation specificity for GFRα receptor molecules, which can be mimetics of glial-derived neurotrophic factor (GDNF) family ligands (GFLs), GFRα/RET signaling pathway agonists, and/or direct RET agonists (activators).
Inventors:
Salma, Malt
Carrelson, Matty
Vesparov, Maxim
Pilves, Méchs
Carrelson, Matty
Vesparov, Maxim
Pilves, Méchs
Application Number:
JP2012542580A
Publication Date:
April 22, 2013
Filing Date:
December 13, 2010
Export Citation:
Assignee:
GeneCode AS
International Classes:
C07D215/46; A61K31/415; A61K31/423; A61K31/429; A61K31/433; A61K31/4706; A61K31/473; A61K31/495; A61K31/496; A61P3/00; A61P3/04; A61P9/10; A61P25/00; A61P25/02; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/24; A61P25/28; A61P27/16; A61P35/00; C07D211/96; C07D217/08; C07D219/12; C07D221/16; C07D231/40; C07D263/56; C07D295/18; C07D295/22; C07D417/04; C07D513/10; A61M5/178
Foreign References:
| US3458525A | 1969-07-29 |
Other References:
JPN6014052254; Ｉ．Ｍ．Ａ． Ａｗａｄ ｅｔ ａｌ．: Ｓｔｕｄｉｅｓ ｉｎ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ ３５ Ｃｈｅｍｉｓｔｒｙ ｏｆ Ｈｅｔｅｒｏｃｙｃｌｉｃ Ｃｏｍｐｏｕｎｄｓ , 1988, ｐ．２０１-２０５
JPN6014052255; Ｂ． Ｊ． Ｓｗｅｅｔｍａｎ ｅｔ ａｌ．: Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１２, 1969, ｐ．８８８-８９１
JPN6014052255; Ｂ． Ｊ． Ｓｗｅｅｔｍａｎ ｅｔ ａｌ．: Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１２, 1969, ｐ．８８８-８９１
Attorney, Agent or Firm:
Junzo Watanabe