Title:
甲状腺ホルモンおよびその塩の製造方法
Document Type and Number:
Japanese Patent JP2013514337
Kind Code:
A
Abstract:
The present invention generally refers to a process for the preparation of L-thyroxine derivatives. More in particular, the present invention relates to a iodination reaction of an aromatic derivative with an appropriate iodinating agent, so to afford the related iodinated compound as disodium salt, which may represent a useful intermediate for the synthesis of the L-thyroxine mono-sodium salt, and the free form thereof.
Inventors:
Carlo Ferris Viscardi
Sonia Gazzetto
Laura Garimberti
Enrico Caperetti
Loredana Sini
Sonia Gazzetto
Laura Garimberti
Enrico Caperetti
Loredana Sini
Application Number:
JP2012543799A
Publication Date:
April 25, 2013
Filing Date:
December 17, 2010
Export Citation:
Assignee:
BRACCO IMAGING S.P.A.
International Classes:
C07C227/16; C07C229/36
Domestic Patent References:
| JPS62153237A | 1987-07-08 |
Foreign References:
| WO2009136249A1 | 2009-11-12 |
Other References:
JPN5013001828; ＣＬＡＹＴＯＮ Ｊ．Ｃ．: 'ＴＨＥ ＳＹＮＴＨＥＳＩＳ ＯＦ ＴＨＹＲＯＸＩＮＥ ＡＮＤ ＲＥＬＡＴＥＤ ＳＵＢＳＴＡＮＣＥＳ． ＰＡＲＴ ＶＩ． ＴＨＥ ＰＲＥＰＡＲＡＴＩＯＮ 以下備考' ＪＯＵＲＮＡＬ ＯＦ ＴＨＥ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ， ＰＥＲＫＩＮ ＴＲＡＮＳＡＣＴＩＯＮＳ ２ , 19500101, Ｐ８４０-８４３, ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Masahiro Nitta
Kure Hidenori
Nobuhiko Akiyama
Samejima Mutsumi
Masahiro Nitta
Kure Hidenori
Nobuhiko Akiyama