1-(5-tert-ブチル-2-フェニル-2H-ピラゾール-3-イル)-3-[2-フルオロ-4-(1-メチル-2-オキソ-2,3-ジヒドロ-1H-イミダゾ[4,5-B]ピリジン-7-イルオキシ)-フェニル]-尿素および関連化合物ならびに治療におけるそれらの使用

Title:

Document Type and Number:

Japanese Patent JP2013518089

Kind Code:

A

Abstract:

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain compounds of the following formula (I) (for convenience, collectively referred to herein as “IP compounds”), which, inter alia, are useful in the treatment of cancer, e.g., cancer characterized by (e.g., driven by) mutant RAS (“mutant RAS cancer”). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions in the treatment of cancer, e.g., mutant RAS cancer.

More Like This:

WO/2004/106334	PROCESS FOR THE PREPARATION OF 1,5-NAPHTHYRIDINE-3-CARBOXY AMIDES BY DIRECT ESTER AMIDATION
WO/2009/153721	NICOTINAMIDE DERIVATIVES

Inventors:

Springer, Caroline
Niklesk-Duvac, AEON
Marais, richard
Niklesk-Duvac, Dan
Zambon, Alfonso
Menar, Delphine

Application Number:

JP2012550510A

Publication Date:

May 20, 2013

Filing Date:

January 27, 2011

Export Citation:

Click for automatic bibliography generation Help

Assignee:

CANCER RESEARCH TECHNOLOGY LIMITED
Institute of Cancer Research: Royal Cancer Hospital

International Classes:

C07D471/04; A61K31/437; A61P35/00; A61P35/02

Domestic Patent References:

JP2005527622A	2005-09-15
JP2009518298A	2009-05-07
JP2009534457A	2009-09-24
JP2008517890A	2008-05-29

Foreign References:

WO2008046003A2	2008-04-17
WO2009077766A1	2009-06-25

Other References:

JPN6014049354; Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ５２（１３）, 2009, ３８８１-３８９１
JPN7014003320; Ｂｌｏｏｄ９６（５）, 2000, １６５５-１６６９
JPN6014049354; Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ５２（１３）, 2009, ３８８１-３８９１
JPN7014003320; Ｂｌｏｏｄ９６（５）, 2000, １６５５-１６６９

Attorney, Agent or Firm:

Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka

Previous Patent: 脂肪酸を調製および精製する方法

Next Patent: 新規化合物及び摂食行動に対するそれらの効果