Title:
高コレステロール血症を処置するための薬剤及び機序
Document Type and Number:
Japanese Patent JP2013520444
Kind Code:
A
Abstract:
A method of treating hypercholesterolemia in mammals, by administering an effective amount of a microbial fermentation product, and regulating genes involved in lipoprotein metabolism. A method of regulating cholesterol levels in a patient by administering an effective amount of a composition chosen from the group consisting of PAZ, specific components isolated from PAZ, chemically synthesized analogues of the components of PAZ, and regulating genes involved in lipoprotein metabolism. A method of treating high cholesterol levels in an individual by administering an effective amount of a microbial fermentation product, up-regulating the expression of at least one of the genes that encode ABCA1, ApoA1, and SRB1, and down-regulating the gene that encodes CETP. A method of preventing the onset of high cholesterol levels and/or a deleterious lipoprotein profile in an individual.
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Inventors:
Summit Weid Gupta
Enrique Second Martinez
Fuzzral H. Sarkar
Dennis M. Calvert
Andrea Gemanu
Kevin Michael Patrie
Tiffany Capri Thomas
Andrew A. Dahl
Enrique Second Martinez
Fuzzral H. Sarkar
Dennis M. Calvert
Andrea Gemanu
Kevin Michael Patrie
Tiffany Capri Thomas
Andrew A. Dahl
Application Number:
JP2012554091A
Publication Date:
June 06, 2013
Filing Date:
February 22, 2011
Export Citation:
Assignee:
Health Enhancement Products, Inc.
International Classes:
A61K36/02; A23L1/30; A61K35/74; A61P3/06; A61P9/10
Domestic Patent References:
| JP2009242267A | 2009-10-22 | |||
| JP2007501852A | 2007-02-01 |
Other References:
JPN6015006342; Ｌｉｐｉｄｓ Ｈｅａｌｔｈ Ｄｉｓ．， ２００７， Ｖｏｌ．６， Ｎｏ．２０， ｐｐ．１-９
JPN6015006344; Ａｒｔｅｒｉｏｓｃｌｅｒ． Ｔｈｒｏｍｂ． Ｖａｓｃ． Ｂｉｏｌ．， ２００４， Ｖｏｌ．２４， Ｎｏ．１０， ｐｐ．１７５５-１７６０
JPN6015006344; Ａｒｔｅｒｉｏｓｃｌｅｒ． Ｔｈｒｏｍｂ． Ｖａｓｃ． Ｂｉｏｌ．， ２００４， Ｖｏｌ．２４， Ｎｏ．１０， ｐｐ．１７５５-１７６０
Attorney, Agent or Firm:
Shinsuke Nakajima