Title:
α-トコフェロールキノン誘導体の合成およびその使用方法
Document Type and Number:
Japanese Patent JP2013522217
Kind Code:
A
Abstract:
The present invention is directed to a method of synthesizing a compound of Formula I: the method comprising oxidizing alpha-tocopherol with a metal salt oxidizing agent to form the compound of Formula I, wherein the stoichiometric ratio (mol/mol) of metal salt oxidizing agent/alpha-tocopherol is 1.6 to 4. The invention is also directed to a method of synthesizing a compound of Formula I, the method comprising (a) hydrolyzing alpha-tocopheryl acetate in the presence of a base; (b) neutralizing the hydrolyzing of (a), thereby forming alpha-tocopherol; and (c) oxidizing the alpha-tocopherol of (b) with a metal salt oxidizing agent to form the compound of Formula I, wherein the stoichiometric ratio (mol/mol) of metal salt oxidizing agent/alpha-tocopherol is 1.6 to 4.
Inventors:
Paisley, Stephen Dee.
Repley, Jason M.
Howie, amor
Ekov, Michael
Repley, Jason M.
Howie, amor
Ekov, Michael
Application Number:
JP2012557202A
Publication Date:
June 13, 2013
Filing Date:
March 09, 2011
Export Citation:
Assignee:
Edison Pharmaceuticals, Inc.
International Classes:
C07C46/06; A61K31/122; A61P3/00; A61P3/10; A61P9/00; A61P11/00; A61P13/02; A61P15/08; A61P25/00; A61P25/02; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/28; A61P27/02; A61P35/00; C07C50/28; C07B53/00
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita