Title:
代謝物プロファイリングを用いた再発乳癌の早期検出
Document Type and Number:
Japanese Patent JP2013522652
Kind Code:
A
Abstract:
A monitoring test for recurrent breast cancer with a high degree of sensitivity and specificity is provided that detects the presence of a panel of multiplicity of biomarkers that were identified using metabolite profiling methods. The test is capable of detecting breast cancer recurrence about a years earlier than current available monitoring diagnostic tests. The panel of biomarkers is identified using a combination of nuclear magnetic resonance (NMR) and two dimensional gas chromatography-mass spectrometry (GC×GC-MS) to produce the metabolite profiles of serum samples. The NMR and GC×GC-MS data are analyzed by multivariate statistical methods to compare identified metabolite signals between samples from patients with recurrence of breast cancer and those from patients having no evidence of disease.
Inventors:
Rough Terry, M. Daniel
Asiago, Vincent Mosetti
Goda, G. A. Nagana
Alvarado, Raidi
Asiago, Vincent Mosetti
Goda, G. A. Nagana
Alvarado, Raidi
Application Number:
JP2013501439A
Publication Date:
June 13, 2013
Filing Date:
March 23, 2011
Export Citation:
Assignee:
PURDUE RESEARCH FOUNDATION
International Classes:
G01N33/50; G01N24/12; G01N27/62; G01N30/88; G01R33/465; G01R33/32
Domestic Patent References:
| JP2010537157A | 2010-12-02 | |||
| JPH08248033A | 1996-09-27 |
Other References:
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Attorney, Agent or Firm:
Hironobu Onda
Makoto Onda
Atsushi Honda
Makoto Onda
Atsushi Honda