サーチュイン活性化因子および活性化アッセイ

Japanese Patent JP2013523189

A

Provided are methods and compositions for detecting a compound that activates a sirtuin deacetylase activity on a fluorescent-free activation substrate in vitro. Further provided are sirtuin modulating compounds of the formulas (I) - (XXI), and related compounds (XXXI), (XXXII), (XXXIII), and (XXXIV), including the fluorescent free-substrate SIRT1 activator compounds of formulas (XL), (XI), (XII), and (XIII).

WO/1998/023774	FEN-1 ENDONUCLEASES, MIXTURES AND CLEAVAGE METHODS
JPH0651708	INDUSTRIAL APPLICABILITY [title of invention] Intermediate of 1,2-dioxetane compound
JP2021505187	CPF1-related methods and compositions for gene editing

Die, han
Thomas, Buoy Riella
Ross, El. Stein
Bruce, Shche Panky Bitch

JP2013505166A

June 17, 2013

April 15, 2011

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Sir Tris Pharmaceuticals, Inc.

C12Q1/34; A61K31/439; A61K31/4439; A61K31/4545; A61K31/496; A61K31/498; A61K31/4995; A61K31/506; A61K31/5377; A61K49/00; A61P3/10; A61P21/02; A61P25/00; A61P25/14; A61P25/16; A61P25/28; C07D401/04; C07D401/14; C07D417/14; C07D513/04; C07D519/00

US20080171797A1	2008-07-17
US20090221020A1	2009-09-03
WO2008156869A2	2008-12-24
US20080171797A1	2008-07-17

JPN6015027700; Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｂｉｏｌｏｇｉｃａｌ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．２８０，　Ｎｏ．１７, 2005, Ｐ．１７０３８-１７０４５
JPN6015027701; Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｂｉｏｌｏｇｉｃａｌ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．２８０，　Ｎｏ．１１, 2005, Ｐ．９７８０-９７８５
JPN6015027702; Ｃｈｅｍ　Ｂｉｏｌ　Ｄｒｕｇ　Ｄｅｓ Ｖｏｌ．７４, 2009, Ｐ．６１９-６２４
JPN6015027699; Ａｎａｌｙｔｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ Ｖｏｌ．３７８, 2008, Ｐ．５３-５９
JPN6015027700; Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｂｉｏｌｏｇｉｃａｌ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．２８０，　Ｎｏ．１７, 2005, Ｐ．１７０３８-１７０４５
JPN6015027701; Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｂｉｏｌｏｇｉｃａｌ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．２８０，　Ｎｏ．１１, 2005, Ｐ．９７８０-９７８５
JPN6015027702; Ｃｈｅｍ　Ｂｉｏｌ　Ｄｒｕｇ　Ｄｅｓ Ｖｏｌ．７４, 2009, Ｐ．６１９-６２４

Hirohito Katsunuma
Yukitaka Nakamura
Noritaka Yokota
Takeyasu Ito
Yuko Matsuyama

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