Title:
複雑なアンプリコンの配列解析
Document Type and Number:
Japanese Patent JP2013524849
Kind Code:
A
Abstract:
There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer, especially lymphoid neoplasms, such as lymphomas and leukemias. Provided herein are methods for using DNA sequencing to identify personalized, or patient-specific biomarkers in patients with lymphoid neoplasms, autoimmune disease and other conditions. Identified biomarkers can be used to determine and/or monitor the disease state for a subject with an associated lymphoid disorder or autoimmune disease or other condition. In particular, the invention provides a sensitive method for monitoring lymphoid neoplasms that undergo clonal evolutions without the need to development alternative assays for the evolved or mutated clones serving as patient-specific biomarkers.
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Inventors:
Faham Marek
Moorhead martin
Willis Thomas
Moorhead martin
Willis Thomas
Application Number:
JP2013509047A
Publication Date:
June 20, 2013
Filing Date:
May 04, 2011
Export Citation:
Assignee:
Sequenta Inc.
International Classes:
C12Q1/68; C12N15/09; C12Q1/04
Domestic Patent References:
| JP2002503954A | 2002-02-05 |
Other References:
JPN6015029904; Ｓｃｉ． Ｔｒａｎｓｌ． Ｍｅｄ．， （２００９）， １， ［１２］， ｐ．１２ｒａ２３
JPN6015029907; Ｌｅｕｋｅｍｉａ， （２００３）， １７， ［２］， ｐ．２２５７-２３１７
JPN6015029909; 加藤郁之進監訳、「ＤＮＡクローニング１-基本技術-（第２版）」， 第２版， 宝酒造株式会社， （１９９７）， ｐ．２５８，２６８-２６９
JPN6015029907; Ｌｅｕｋｅｍｉａ， （２００３）， １７， ［２］， ｐ．２２５７-２３１７
JPN6015029909; 加藤郁之進監訳、「ＤＮＡクローニング１-基本技術-（第２版）」， 第２版， 宝酒造株式会社， （１９９７）， ｐ．２５８，２６８-２６９
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto