Title:
グリセオリンを有効成分として含む骨疾患治療用組成物
Document Type and Number:
Japanese Patent JP2013528583
Kind Code:
A
Abstract:
The present invention relates to a composition for preventing or treating a bone disease, comprising glyceollin as an active ingredient. The active ingredient, glyceollin promotes degradation of the Runx2 protein in osteoblasts and inhibits the mRNA expression of Rankl in osteoblasts to prevent the differentiation of osteoclasts. Furthermore, glyceollin is capable of ameliorating osteoporosis in animal models for osteoporosis. The present composition is a promising drug or food for prevention or treatment of not only osteoporosis but also bone diseases caused by cancer metastatic to the bone.
Inventors:
Choi Jae Young
Han Min Soo
John Zefan
Lim Kyung Eun
Kim Young Hoon
Hwang Yong Hyun
Kim In Gyom
Han Min Soo
John Zefan
Lim Kyung Eun
Kim Young Hoon
Hwang Yong Hyun
Kim In Gyom
Application Number:
JP2013507885A
Publication Date:
July 11, 2013
Filing Date:
April 28, 2011
Export Citation:
Assignee:
Kyung Buk National University Industry-Academic Coop Foundation
International Classes:
A61K31/352; A23L1/30; A61P19/08; A61P43/00; C07D493/14
Foreign References:
| WO2009111428A2 | 2009-09-11 |
Other References:
JPN6014007320; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｆｏｏｄ Ｖｏｌ．１３， Ｎｏ．２, 20100301, ｐｐ．１-９
Attorney, Agent or Firm:
Koichi Hirota
Yoshihiro Nagare
Naoko Matsuda
Yoshihiro Nagare
Naoko Matsuda