Title:
NGALタンパク質変異体及びその使用
Document Type and Number:
Japanese Patent JP2013529907
Kind Code:
A
Abstract:
In one aspect the present invention is directed to mutant Neutrophil gelatinase-associated lipocalin (NGAL) proteins that have the ability to bind to siderophores, such as enterochelin, and to chelate and transport iron, and that are excreted in the urine. Such NGAL mutants, and complexes thereof with siderophores, can be used to clear excess iron from the body, for example in the treatment of iron overload. The NGAL mutants of the invention also have antibacterial activity and can be used in the treatment of bacterial infections, such as those of the urinary tract.
Inventors:
Barash Jonathan
Chiu Andong
Chiu Andong
Application Number:
JP2013512169A
Publication Date:
July 25, 2013
Filing Date:
May 24, 2011
Export Citation:
Assignee:
The Trustees of Columbia University in the City of New York
International Classes:
C12N15/09; A61K31/05; A61K31/192; A61K38/00; A61P31/04; C07K14/47; C12N1/21; C12N5/10
Attorney, Agent or Firm:
Koichi Tsujii
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Takamitsu Hoshino
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Takamitsu Hoshino