Title:
組成物
Document Type and Number:
Japanese Patent JP2013533230
Kind Code:
A
Abstract:
The present invention is directed to a buprenorphine sustained release delivery system capable of delivering buprenorphine, a metabolite, or a prodrug thereof for a duration of about 14 days to about 3 months. The buprenorphine sustained release delivery system includes a flowable composition and a solid implant for the sustained release of buprenorphine, a metabolite, or a prodrug thereof. The implant is produced from the flowable composition. The buprenorphine sustained release delivery system provides in situ 1-month and 3-month release profiles characterized by an exceptionally high bioavailability and minimal risk of permanent tissue damage and typically no risk of muscle necrosis.
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Inventors:
Norton Richard El
Watkins Andrew
Chow Min Shin
Watkins Andrew
Chow Min Shin
Application Number:
JP2013513755A
Publication Date:
August 22, 2013
Filing Date:
June 06, 2011
Export Citation:
Assignee:
R.B. Pharmaceuticals Limited
International Classes:
A61K31/485; A61K9/08; A61K47/22; A61K47/34; A61K47/44; A61L27/00; A61P25/04; A61P25/36; A61P29/00
Domestic Patent References:
| JP2006508127A | 2006-03-09 | |||
| JP2008520547A | 2008-06-19 |
Foreign References:
| WO2009091737A2 | 2009-07-23 | |||
| WO2009091737A2 | 2009-07-23 |
Other References:
JPN6015015893; ＡＡＰＳ ＰｈａｒｍＳｃｉＴｅｃｈ Ｖｏｌ．８， Ｎｏ．３, 2007, ｐ．Ｅ１-Ｅ４
Attorney, Agent or Firm:
Koichi Tsujii
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa