Title:
免疫抑制調節化合物
Document Type and Number:
Japanese Patent JP2013534922
Kind Code:
A
Abstract:
The present invention provides immunosuppression compounds capable of inhibiting the programmed cell death 1 (PD1) signalling pathway. The present invention further provides peptide based compositions for treatment of cancer or treatment of infections via immunopotentiation caused by inhibition of immunosuppressive signaling induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient. Further, the invention provides an application of the compositions containing the peptide moieties for preventive and/or therapeutic agents for cancer, cancer metastasis, immunodeficiency, an infectious disease or the like and an application of peptide moieties as a testing or diagnostic agent or a research agent for such a disease.
Inventors:
Sasikkumar, Potile, Govindan, Nair
Ramachandra, Muraridhara
Vadramani, Slesh, Kumar
Vemura, Koteswara, Lao
Satyam, lina, hare
Suvarao, Krishna Prasad
Shrimari, Rajiv, Kay.
Candep, Srinivasa
Ramachandra, Muraridhara
Vadramani, Slesh, Kumar
Vemura, Koteswara, Lao
Satyam, lina, hare
Suvarao, Krishna Prasad
Shrimari, Rajiv, Kay.
Candep, Srinivasa
Application Number:
JP2013516061A
Publication Date:
September 09, 2013
Filing Date:
June 27, 2011
Export Citation:
Assignee:
AURIGENE DISCOVERY TECHNOLOGIES LIMITED
International Classes:
C07K14/47; A61K38/00; A61P31/00; A61P31/04; A61P31/12; A61P35/00; A61P35/02; A61P35/04; A61P37/02
Domestic Patent References:
| JP2008543774A | 2008-12-04 | |||
| JP2002112782A | 2002-04-16 | |||
| JP2001521386A | 2001-11-06 |
Foreign References:
| WO2007100098A1 | 2007-09-07 | |||
| WO2009025806A2 | 2009-02-26 |
Other References:
PNAS, vol. 105, no. 8, JPN6015024971, 2008, pages 3011 - 3016, ISSN: 0003100715
GENE, vol. 197, JPN6015024972, 1997, pages 177 - 187, ISSN: 0003100716
PNAS, vol. 105, no. 30, JPN6015024975, 2008, pages 10275 - 10276, ISSN: 0003100717
IMMUNOLOGY, vol. 124, JPN6015024977, 2008, pages 277 - 293, ISSN: 0003100718
GENE, vol. 197, JPN6015024972, 1997, pages 177 - 187, ISSN: 0003100716
PNAS, vol. 105, no. 30, JPN6015024975, 2008, pages 10275 - 10276, ISSN: 0003100717
IMMUNOLOGY, vol. 124, JPN6015024977, 2008, pages 277 - 293, ISSN: 0003100718
Attorney, Agent or Firm:
Kishimoto Tatsuto
Akihiko Yamashita
Noriyuki Yamamoto
Akihiko Yamashita
Noriyuki Yamamoto