Title:
置換されたヌクレオチドアナログ
Document Type and Number:
Japanese Patent JP2013537907
Kind Code:
A
Abstract:
Disclosed herein are phosphorothioate nucleotide analogs, such as thiophosphoramidate prodrugs and thiohosphates (including α-thiomonophosphates, α-thiodiphosphates, and α-thiotriphosphates), methods of synthesizing phosphorothioate nucleotide analogs, such as thiophosphoramidate prodrugs and thiophosphates, and methods of treating viral infections such as HCV, with the phosphorothioate nucleotide analogs, such as thiophosphoramidate prodrugs and thiophosphates.
Inventors:
Smith, David, Bernard
Duval, Jerome
Diatkina, Natalia
Begelmann, Leonid
One, Gwangyi
Duval, Jerome
Diatkina, Natalia
Begelmann, Leonid
One, Gwangyi
Application Number:
JP2013530217A
Publication Date:
October 07, 2013
Filing Date:
September 19, 2011
Export Citation:
Assignee:
Arios Biopharma Inc.
International Classes:
C07H19/10; A61K31/343; A61K31/381; A61K31/4178; A61K31/422; A61K31/4709; A61K31/501; A61K31/519; A61K31/549; A61K31/7056; A61K31/7068; A61K31/7072; A61K31/7076; A61K31/708; A61K38/00; A61K38/21; A61K45/00; A61P31/12; A61P31/14; A61P31/16; A61P31/20; A61P31/22; A61P43/00; C07H19/20; C07H19/207
Domestic Patent References:
| JP2010510301A | 2010-04-02 | |||
| JP2009526850A | 2009-07-23 | |||
| JP2009504704A | 2009-02-05 | |||
| JP2008504265A | 2008-02-14 | |||
| JP2007509939A | 2007-04-19 |
Foreign References:
| CN1343673A | 2002-04-10 | |||
| WO2006121820A1 | 2006-11-16 | |||
| WO2006116557A1 | 2006-11-02 | |||
| WO2010081082A2 | 2010-07-15 | |||
| WO2008121634A2 | 2008-10-09 | |||
| US20060074035A1 | 2006-04-06 | |||
| EP2166016A1 | 2010-03-24 |
Other References:
SYNTHESIS, vol. 13, JPN6015023788, 2003, pages 1989 - 1994, ISSN: 0003096342
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. Vol.47(8), JPN6015023787, 2003, pages 2674 - 2681, ISSN: 0003096343
化学大辞典３, JPN6016012452, 30 September 1960 (1960-09-30), pages 289, ISSN: 0003290778
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. Vol.47(8), JPN6015023787, 2003, pages 2674 - 2681, ISSN: 0003096343
化学大辞典３, JPN6016012452, 30 September 1960 (1960-09-30), pages 289, ISSN: 0003290778
Attorney, Agent or Firm:
Patent Business Corporation Unias International Patent Office