環状リポペプチド化合物又はその塩の精製方法 - Shanghai Tianwei Biopharmaceutical Co., Ltd.

Title:

環状リポペプチド化合物又はその塩の精製方法

Document Type and Number:

Japanese Patent JP2013538832

Kind Code:

A

Abstract:

A process for purifying cyclic lipopeptide compounds or salts thereof comprising the steps of: (1) charging a crude compound of Formula I onto a macroporous adsorption resin; (2) washing the macroporous adsorption resin using water, an organic solvent or a mixed solution of an organic solvent and water as a washing liquid; and (3) eluting the compound of Formula I from the macroporous adsorption resin using water, an organic solvent or a mixed solution of an organic solvent and water as an eluent. The purification method has the advantages of using a small amount of organic solvents, using no silica gel, and causing little damage to the environment; the purity of the collected compound of formula I is also improved as compared with the methods previously disclosed.

Inventors:

Zhang
Liu Shidong
Tadahiro Taku
Lee

Application Number:

JP2013530549A

Publication Date:

October 17, 2013

Filing Date:

September 27, 2011

Export Citation:

Click for automatic bibliography generation Help

Assignee:

Shanghai Tianwei Biopharmaceutical Co., Ltd.

International Classes:

C07K5/12; C07K1/20

Domestic Patent References:

JPH03184921A	1991-08-12
JPH05966A	1993-01-08
JP2003511345A	2003-03-25
JP2013538833A	2013-10-17
JPH04352799A	1992-12-07
JP2004524318A	2004-08-12
JPH03184921A	1991-08-12
JPH05966A	1993-01-08
JP2003511345A	2003-03-25
JP2013538833A	2013-10-17

Foreign References:

US20080076149A1	2008-03-27
US5376634A	1994-12-27
EP0933422A1	1999-08-04
US20080076149A1	2008-03-27
US5376634A	1994-12-27
EP0933422A1	1999-08-04

Other References:

JPN6015039082; Ｒ．Ｋａｎａｓａｋｉ，　ｅｔ　ａｌ．，　Ｊ．　Ａｎｔｉｂｉｏｔ．，　２００６，　５９（３），　ｐｐ１３７-１４４
JPN6015039082; Ｒ．Ｋａｎａｓａｋｉ，　ｅｔ　ａｌ．，　Ｊ．　Ａｎｔｉｂｉｏｔ．，　２００６，　５９（３），　ｐｐ１３７-１４４

Attorney, Agent or Firm:

Nagoya International Patent Service Corporation

Previous Patent: Ｃ型肝炎ウィルス感染治療のための四環式インドール誘導体

Next Patent: 環状リポペプチド化合物又はその塩の精製方法