Title:
メディトープ(Meditope)のためのモノクローナル抗体フレームワーク結合インターフェース、メディトープ送達系、およびその使用法
Document Type and Number:
Japanese Patent JP2013541542
Kind Code:
A
Abstract:
An antibody framework binding interface for the cyclic meditopes C-QFDLSTRRLK-C (cQFD; SEQ ID NO:1) and C-QYNLSSRALK-C (cQYN; SEQ ID NO:2) and methods for their use are provided herein. In one embodiment, a binding interface is formed by a framework region, and not a complementarity determining region (CDR), of an antibody or functional fragment thereof. In another embodiment, a therapeutic human or humanized antibody has one or more human framework residues replaced with one or more corresponding murine residues such that a meditope having the sequence cQFD or cQYN stably binds the one or more human framework residues.
Inventors:
Williams, John Sea.
Donaldson, Joshua, Michael
Horn, david, a
Ma, Yuelon
The, Cindy
Bizmek, Christoph
Avery, Kendra, Nicole
Donaldson, Joshua, Michael
Horn, david, a
Ma, Yuelon
The, Cindy
Bizmek, Christoph
Avery, Kendra, Nicole
Application Number:
JP2013533010A
Publication Date:
November 14, 2013
Filing Date:
October 10, 2011
Export Citation:
Assignee:
Williams, John Sea.
Donaldson, Joshua, Michael
Horn, david, a
Ma, Yuelon
The, Cindy
Bizmek, Christoph
Avery, Kendra, Nicole
Donaldson, Joshua, Michael
Horn, david, a
Ma, Yuelon
The, Cindy
Bizmek, Christoph
Avery, Kendra, Nicole
International Classes:
C07K16/18; A61K39/395; A61K49/00; A61K51/00; A61P35/00; C07K1/22; C12P21/08; G01N33/53; G01N33/577
Foreign References:
| WO2005056606A2 | 2005-06-23 |
Other References:
PROC. NATL. ACAD. SCI. U.S.A., vol. 97, no. 10, JPN6015033979, 2000, pages 5399 - 5404, ISSN: 0003140961
STRUCTURE, vol. 9, JPN6015033981, 2001, pages 679 - 687, ISSN: 0003140962
J. NATL. CANCER INST., vol. 97, no. 22, JPN6016023589, 2005, pages 1663 - 1670, ISSN: 0003483173
J. IMMUNOL. METHODS, vol. 233, JPN6016023590, 2000, pages 77 - 81, ISSN: 0003342988
J. NATL. CANCER INST., vol. 97, no. 22, JPN6015033982, 2005, pages 1663 - 1670, ISSN: 0003140963
STRUCTURE, vol. 9, JPN6015033981, 2001, pages 679 - 687, ISSN: 0003140962
J. NATL. CANCER INST., vol. 97, no. 22, JPN6016023589, 2005, pages 1663 - 1670, ISSN: 0003483173
J. IMMUNOL. METHODS, vol. 233, JPN6016023590, 2000, pages 77 - 81, ISSN: 0003342988
J. NATL. CANCER INST., vol. 97, no. 22, JPN6015033982, 2005, pages 1663 - 1670, ISSN: 0003140963
Attorney, Agent or Firm:
Seiji Ohno
Keiko Kanemoto
Reiko Tanaka
Yuko Matsuniya
Ken Kitano
Natsuki Ito
Umeda Shinsuke
Keiko Kanemoto
Reiko Tanaka
Yuko Matsuniya
Ken Kitano
Natsuki Ito
Umeda Shinsuke