Title:
三環系PI3K阻害剤化合物及びその使用方法
Document Type and Number:
Japanese Patent JP2014503535
Kind Code:
A
Abstract:
Tricyclic PI3k inhibitor compounds of Formula I with anti-cancer activity, antiinflammatory activity, or immunoregulatory properties, and more specifically with PI3 kinase modulating or inhibitory activity are described. Methods are described for using the tricyclic PI3K inhibitor compounds of Formula I for in vitro, in situ , and in vivo diagnosis or treatment of mammalian cells, organisms, or associated pathological conditions. Formula I compounds include stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof. The dashed lines indicate an optional double bond, and at least one dashed line is a double bond. The substituents are as described.
Inventors:
Dotson, jennifer
Heald, robert andrew
Heflon, Timothy
Jones, Graham Elgin
Clintel, Suzie Larche
McLean, Neville James
Ndubak, Tudy
Olivero, Alangie.
Sulphati, laurent
One, run
Way, binchin
Heald, robert andrew
Heflon, Timothy
Jones, Graham Elgin
Clintel, Suzie Larche
McLean, Neville James
Ndubak, Tudy
Olivero, Alangie.
Sulphati, laurent
One, run
Way, binchin
Application Number:
JP2013544769A
Publication Date:
February 13, 2014
Filing Date:
December 15, 2011
Export Citation:
Assignee:
Ef Hoffman-La Roche Akchengezel Shaft
International Classes:
C07D487/14; A61K31/5383; A61K31/5386; A61K39/395; A61K45/00; A61P35/00; A61P35/02; A61P43/00; C07D491/147; C07D495/14; C07D498/12; C07D519/00
Domestic Patent References:
| JPS4872196A | 1973-09-29 | |||
| JP2013502404A | 2013-01-24 |
Foreign References:
| WO2009146406A1 | 2009-12-03 | |||
| WO2010052569A2 | 2010-05-14 | |||
| US20030236271A1 | 2003-12-25 |
Other References:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, JPN6014038474, 2007, pages 2438 - 2442, ISSN: 0003084458
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori
Kobayashi Yoshinori