Title:
ErbB経路阻害剤に対する耐性の克服
Document Type and Number:
Japanese Patent JP2014509593
Kind Code:
A
Abstract:
Provided are methods for overcoming resistance to an ErbB pathway inhibitor, such as an EGFR inhibitor or a HER2 inhibitor. The resistance may be acquired resistance to an EGFR inhibitor, such as acquired resistance to gefitinib. In the methods provided, a subject exhibiting resistance to an ErbB pathway inhibitor is selected and both an ErbB 3 inhibitor and a second ErbB pathway inhibitor are administered to the subject, such as an EGFR inhibitor or a HER2 inhibitor. Also provided are methods for inhibiting the growth of a tumor comprising a T790M EGFR mutation by contacting the tumor with an ErbB3 inhibitor and an EGFR inhibitor. Compositions for overcoming resistance to an ErbB pathway inhibitor, comprising both an ErbB 3 inhibitor and a second ErbB pathway inhibitor, such as an EGFR inhibitor or a HER2 inhibitor, are also provided.
Inventors:
Garcia Gabriella
Kubasek William
Lahaden Lanta Maria Johanna
McBeth Gavin
McDonner Charlotte
Moi Victor
Onsum Matthew David
Seveska mark
Weiss Selbaum Marisa
Chang Bo
Chauvard Birgit
Kubasek William
Lahaden Lanta Maria Johanna
McBeth Gavin
McDonner Charlotte
Moi Victor
Onsum Matthew David
Seveska mark
Weiss Selbaum Marisa
Chang Bo
Chauvard Birgit
Application Number:
JP2013558187A
Publication Date:
April 21, 2014
Filing Date:
March 15, 2012
Export Citation:
Assignee:
Merrimack Pharmaceuticals Inc.
International Classes:
A61K45/06; A61K31/4706; A61K31/517; A61K31/5377; A61K33/243; A61K39/395; A61P35/00; A61P43/00; C12N15/09
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto