Title:
テルペンの生産のための酵母細胞およびその使用
Document Type and Number:
Japanese Patent JP2014510524
Kind Code:
A
Abstract:
The present invention relates to a yeast cell, wherein said cell comprises a functional gene coding for soluble hydroxymethylglutaryl-coenzyme-A (HMG-CoA) reductase; one or more gene(s) coding for steryl acyltransferase(s) in said cell are defective or deleted; and said cell is prototrophic for at least histidine, leucine or uracil. Moreover, the present invention relates to the use of said cell for the production of one or more terpene(s). Further, the present invention relates to methods of generating said cell and the production of one or more terperne(s) and a pharmaceutical or cosmetically composition, a lubricant or transformer oil comprising said terpene(s).
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Inventors:
Raab Andreas
Lang Christine
Lang Christine
Application Number:
JP2013555777A
Publication Date:
May 01, 2014
Filing Date:
February 15, 2012
Export Citation:
Assignee:
Organo Balance Game Bha
International Classes:
C12N15/09; A61K8/31; A61Q19/00; C10M105/04; C10M177/00; C12N1/19; C12P5/02; C10N40/16; C10N70/00
Foreign References:
| WO2002053746A1 | 2002-07-11 |
Other References:
JPN6016000978; Ａｐｐｌ Ｍｉｃｒｏｂｉｏｌ Ｂｉｏｔｅｃｈｎｏｌ， １９９８， ｖｏｌ．４９， ｐ．６６-７１
JPN6016000980; Ｊ Ｂｉｏｌ Ｃｈｅｍ． ２０１０， ｖｏｌ．２８５， ｎｏ．９， ｐ．６１２７-６１３３
JPN6016000982; Ｙｅａｓｔ， ２００４， ｖｏｌ．２１， ｎｏ．１４， ｐ．１２０５-１２１７
JPN6016000980; Ｊ Ｂｉｏｌ Ｃｈｅｍ． ２０１０， ｖｏｌ．２８５， ｎｏ．９， ｐ．６１２７-６１３３
JPN6016000982; Ｙｅａｓｔ， ２００４， ｖｏｌ．２１， ｎｏ．１４， ｐ．１２０５-１２１７
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto