Title:
新規セファロスポリン誘導体およびその医薬組成物
Document Type and Number:
Japanese Patent JP2014510750
Kind Code:
A
Abstract:
The present invention relates to novel cephalosporin derivatives represented by Chemical Formula 1.
Wherein, X, Y, L, R 1 , and R 2 are as same as defined in the description of the invention. The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient. According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.
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Inventors:
Cho, Yong Rak
Yoon, Jeong Yul
Park Seul Seung
Choi, San Eun
Lee, Hwang Suk
Oh, Cuman
Hye Jin
Kang, Te Hyuk
Yang, Yong Choi
Kwon, Hyun Chin
Park, Te Kyo
U, Song Ho
Kim, Yong Tsu
Yoon, Jeong Yul
Park Seul Seung
Choi, San Eun
Lee, Hwang Suk
Oh, Cuman
Hye Jin
Kang, Te Hyuk
Yang, Yong Choi
Kwon, Hyun Chin
Park, Te Kyo
U, Song Ho
Kim, Yong Tsu
Application Number:
JP2014502466A
Publication Date:
May 01, 2014
Filing Date:
March 29, 2012
Export Citation:
Assignee:
LEGOCHEM Biosciences, Inc.
International Classes:
C07D501/24; A61K31/546; A61P31/04; C07D501/56
Domestic Patent References:
| JPH06510523A | 1994-11-24 | |||
| JPH02117678A | 1990-05-02 |
Foreign References:
| WO2003078440A1 | 2003-09-25 | |||
| WO2010050468A1 | 2010-05-06 | |||
| AU2005202802A1 | 2006-01-12 |
Other References:
KIM, YONG-ZU; LIM, JONG-CHAN; YEO, JAE-HONG; BANG, CHAN-SIK; KIM, SAM-SIK; LEE, TAE HEE; OH, SEONG H: "Synthesis and antibacterial activities of novel C(3)-pyrimidine(thiol)-substituted cephalosporins", KOREAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 6, no. 1, JPN6015048689, 1996, pages 15 - 21, ISSN: 0003541239
AU 2005202802 A1, JPN7015003412, 12 January 2006 (2006-01-12), ISSN: 0003209853
AU 2005202802 A1, JPN7015003412, 12 January 2006 (2006-01-12), ISSN: 0003209853
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Yoshida Juri
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Yoshida Juri