Title:
miRNAに基づくユニバーサルスクリーニングテスト(UST)
Document Type and Number:
Japanese Patent JP2014511709
Kind Code:
A
Abstract:
Described are methods for early diagnosis and progression monitoring of Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD) by quantifying neurite and/or synapse miRNAs in bodily fluids.
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Inventors:
Shainer Man, Kailas.
Zyvinsky, Vladimir
Umansky, Samil Earl.
Zyvinsky, Vladimir
Umansky, Samil Earl.
Application Number:
JP2014506516A
Publication Date:
May 19, 2014
Filing Date:
April 18, 2012
Export Citation:
Assignee:
DIAMIR,LLC
International Classes:
C12Q1/68; C12N15/09
Domestic Patent References:
| JP2010536372A | 2010-12-02 |
Foreign References:
| WO2009143379A2 | 2009-11-26 | |||
| WO2009133915A1 | 2009-11-05 |
Other References:
MIYACHI, M. ET AL.: ""Circulating muscle-specific microRNA, miR-206, as a potential diagnostic marker for rhabdomyosarcom", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 400, JPN6016013056, 2010, pages 89 - 93, XP027275786, ISSN: 0003293218, DOI: 10.1016/j.bbrc.2010.08.015
LIANG, Y.: ""An expression meta-analysis of predicted microRNA targets identifies a diagnostic signature for lun", BMC MED. GENOMICS., vol. Vol. 1: 61, JPN7016000877, 2008, pages 1 - 16, ISSN: 0003293219
WEBER, J. A. ET AL.: ""The microRNA spectrum in 12 body fluids"", CLIN. CHEM., vol. 56, JPN6016013059, 2010, pages 1733 - 1741, XP055188106, ISSN: 0003619970, DOI: 10.1373/clinchem.2010.147405
LIANG, Y.: ""An expression meta-analysis of predicted microRNA targets identifies a diagnostic signature for lun", BMC MED. GENOMICS., vol. Vol. 1: 61, JPN7016000877, 2008, pages 1 - 16, ISSN: 0003293219
WEBER, J. A. ET AL.: ""The microRNA spectrum in 12 body fluids"", CLIN. CHEM., vol. 56, JPN6016013059, 2010, pages 1733 - 1741, XP055188106, ISSN: 0003619970, DOI: 10.1373/clinchem.2010.147405
Attorney, Agent or Firm:
Kiyoji Kuzuwa