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Title:
混晶アゴメラチン(VIII型)、その調製方法及び使用、並びにこれを含有する医薬組成物
Document Type and Number:
Japanese Patent JP2014516921
Kind Code:
A
Abstract:
The present invention provides a mixed crystalline form VIII of agomelatine, its method of preparation, application and pharmaceutical composition. The said mixed crystal consists mainly of crystalline form VI of agomelatine. The said mixed crystalline form is stable and has good reproducibility. Through stability tests, it has been found to be superior to the crystalline form VI in terms of stability. As a result, the crystalline form VIII of the present invention possesses advantages in pharmaceutical preparation.

Inventors:
Fan, you
Ron, Chin
Ju, Shwe Yang
Shan, Hanbin
Ewan, Jeddon
You
Application Number:
JP2014500244A
Publication Date:
July 17, 2014
Filing Date:
March 22, 2012
Export Citation:
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Assignee:
Shanghai Institute of Pharmaceutical Industry
International Classes:
C07C235/34; A61K31/165; A61P1/00; A61P9/00; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P43/00; C07C231/24
Foreign References:
WO2011054917A12011-05-12
WO2011154140A22011-12-15
WO2012046253A22012-04-12
CN102452952A2012-05-16
WO2010102554A12010-09-16
WO2011006387A12011-01-20
WO2011075943A12011-06-30
Attorney, Agent or Firm:
Patent business corporation Tsukuni
Hajime Tsukuni
Yasuo Yanagibashi
Satoko Ito
Keiko Ozawa
Toshio Miyake
Yasuhiro Oguni
Yoko Tanaka
Yoshinori Ikukawa
Akio Shibata
Atsushi Shiomi



 
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