Title:
粘度が低減された処方物
Document Type and Number:
Japanese Patent JP2014516924
Kind Code:
A
Abstract:
The present invention is directed to a method for reducing the viscosity of a formulation containing citrate and a therapeutic protein and formulations made using the claimed method.
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Inventors:
Manna, A. Monk
Man, Lee, Won
Kai, Tsang
Man, Lee, Won
Kai, Tsang
Application Number:
JP2014504013A
Publication Date:
July 17, 2014
Filing Date:
April 06, 2012
Export Citation:
Assignee:
GlaxoSmithKline LLC
International Classes:
A61K38/00; A61K9/08; A61K39/395; A61K47/02; A61K47/12; A61K47/18; A61K47/26; A61K47/34; C07K16/24
Domestic Patent References:
| JP2007524602A | 2007-08-30 | |||
| JP2004532798A | 2004-10-28 | |||
| JP2014510152A | 2014-04-24 | |||
| JP2013518852A | 2013-05-23 | |||
| JP2013517277A | 2013-05-16 | |||
| JP2010513522A | 2010-04-30 | |||
| JP2009521482A | 2009-06-04 | |||
| JP2007511566A | 2007-05-10 |
Foreign References:
| WO2009068649A2 | 2009-06-04 | |||
| WO2009084659A1 | 2009-07-09 | |||
| WO2007074880A1 | 2007-07-05 |
Other References:
SUKUMAR,M. ET AL.: "Opalescent appearance of an IgG1 antibody at high concentrations and its relationship to noncovalent", PHARM. RES., vol. 21, no. 7, JPN6016004920, July 2004 (2004-07-01), pages 1087 - 93, ISSN: 0003252722
SHIRE,S.J. ET AL.: "High-concentration antibody formulations.", FORMULATION AND PROCESS DEVELOPMENT STRATEGIES FOR MANUFACTURING BIOPHARMACEUTICALS., JPN6016004923, 1 January 2010 (2010-01-01), pages 349 - 81, XP055050466, ISSN: 0003252723, DOI: 10.1002/9780470595886.ch15
HE,F. ET AL.: "Screening of monoclonal antibody formulations based on high-throughput thermostability and viscosity", J. PHARM. SCI., vol. 100, no. 4, JPN6016004918, 2 November 2010 (2010-11-02), pages 1330 - 40, XP002696416, ISSN: 0003252724, DOI: 10.1002/jps.22384
SHIRE,S.J. ET AL.: "High-concentration antibody formulations.", FORMULATION AND PROCESS DEVELOPMENT STRATEGIES FOR MANUFACTURING BIOPHARMACEUTICALS., JPN6016004923, 1 January 2010 (2010-01-01), pages 349 - 81, XP055050466, ISSN: 0003252723, DOI: 10.1002/9780470595886.ch15
HE,F. ET AL.: "Screening of monoclonal antibody formulations based on high-throughput thermostability and viscosity", J. PHARM. SCI., vol. 100, no. 4, JPN6016004918, 2 November 2010 (2010-11-02), pages 1330 - 40, XP002696416, ISSN: 0003252724, DOI: 10.1002/jps.22384
Attorney, Agent or Firm:
Hirohito Katsunuma
Noritaka Yokota
Hiroshi Sorimachi
Omori Miko
Noritaka Yokota
Hiroshi Sorimachi
Omori Miko