Title:
グルコシルセラミド合成酵素阻害剤
Document Type and Number:
Japanese Patent JP2014517808
Kind Code:
A
Abstract:
The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
Inventors:
Elysee Bourke
Cassandra Seratka
Bradford Hearth
Marx Metz
Joan Jao
Renato Skelly
Evin Shearn
Catherine Jansix
John Marshall
Suong Chu Young
Ronald Sur
Mario Cabrera-Salazar
Andrew Good
Cassandra Seratka
Bradford Hearth
Marx Metz
Joan Jao
Renato Skelly
Evin Shearn
Catherine Jansix
John Marshall
Suong Chu Young
Ronald Sur
Mario Cabrera-Salazar
Andrew Good
Application Number:
JP2013558205A
Publication Date:
July 24, 2014
Filing Date:
March 16, 2012
Export Citation:
Assignee:
GENZYME CORPORATION
International Classes:
C07D453/02; A61K31/439; A61K31/551; A61P3/00; A61P25/00; A61P25/16; A61P25/28; A61P35/00; A61P43/00; C07D487/08
Domestic Patent References:
| JPH03197462A | 1991-08-28 | |||
| JP2000500139A | 2000-01-11 | |||
| JP2008504282A | 2008-02-14 | |||
| JP2005533799A | 2005-11-10 | |||
| JP2002302490A | 2002-10-18 | |||
| JP2003532731A | 2003-11-05 | |||
| JP2002540208A | 2002-11-26 |
Foreign References:
| WO1995021820A1 | 1995-08-17 | |||
| WO2010015324A1 | 2010-02-11 | |||
| WO2005073183A1 | 2005-08-11 | |||
| WO2004011430A1 | 2004-02-05 |
Other References:
DEMIAN, IULIA; GRIPSHOVER, DAVID F.: "Enantiomeric purity determination of 3-aminoquinuclidine by diastereomeric derivatization and high-p", JOURNAL OF CHROMATOGRAPHY, vol. 466, JPN6015043558, 1989, pages 415 - 20, XP026479517, ISSN: 0003186636, DOI: 10.1016/S0021-9673(01)84640-9
MASHKOVSKII, M. D.: "The relation between the chemical structure and pharmacological activity of some esters of 3-hydroxy", PROC. INTERN. PHARMACOL. MEETING, 1ST, STOCKHOLM, 1961, vol. 7, JPN6015043560, 1963, pages 359 - 66, ISSN: 0003186637
MIKHLINA, E. E.; RUBTSOV, M. V.: "New paths of synthesis of 3-quinuclidineacetic acid", ZHURNAL OBSHCHEI KHIMII, vol. 30, JPN6015043562, 1960, pages 2970 - 7, ISSN: 0003186638
HORAK, JEANNIE; HOFER, STEFAN; LINDNER, WOLFGANG: "Optimization of a ligand immobilization and azide group endcapping concept via "Click-Chemistry" for", JOURNAL OF CHROMATOGRAPHY B: ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, vol. 878(32), JPN6015043563, 2010, pages 3382 - 3394, ISSN: 0003186639
CERBAI, G.; TURBANTI, L.; TELLINI, N.; FABRIZI, P.; DELL'OMODARME, G.: "Acetylene derivatives with antispastic activity. II. Amino esters of propylpropargylacetic acid", FARMACO, EDIZIONE SCIENTIFICA, vol. 27(3), JPN6015043564, 1972, pages 217 - 34, ISSN: 0003186640
REGISTRY(STN)[ONLINE], JPN7015003000, ISSN: 0003186641
MASHKOVSKII, M. D.: "The relation between the chemical structure and pharmacological activity of some esters of 3-hydroxy", PROC. INTERN. PHARMACOL. MEETING, 1ST, STOCKHOLM, 1961, vol. 7, JPN6015043560, 1963, pages 359 - 66, ISSN: 0003186637
MIKHLINA, E. E.; RUBTSOV, M. V.: "New paths of synthesis of 3-quinuclidineacetic acid", ZHURNAL OBSHCHEI KHIMII, vol. 30, JPN6015043562, 1960, pages 2970 - 7, ISSN: 0003186638
HORAK, JEANNIE; HOFER, STEFAN; LINDNER, WOLFGANG: "Optimization of a ligand immobilization and azide group endcapping concept via "Click-Chemistry" for", JOURNAL OF CHROMATOGRAPHY B: ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, vol. 878(32), JPN6015043563, 2010, pages 3382 - 3394, ISSN: 0003186639
CERBAI, G.; TURBANTI, L.; TELLINI, N.; FABRIZI, P.; DELL'OMODARME, G.: "Acetylene derivatives with antispastic activity. II. Amino esters of propylpropargylacetic acid", FARMACO, EDIZIONE SCIENTIFICA, vol. 27(3), JPN6015043564, 1972, pages 217 - 34, ISSN: 0003186640
REGISTRY(STN)[ONLINE], JPN7015003000, ISSN: 0003186641
Attorney, Agent or Firm:
Junji Yuda
Noriyuki Takebayashi
Noriyuki Takebayashi