Title:
炭酸脱水酵素標的化剤およびそれの使用方法
Document Type and Number:
Japanese Patent JP2014520076
Kind Code:
A
Abstract:
The invention provides agents that target carbonic anhydrase, which can be used as imaging agents or therapeutic agents. The agents can be used to image tumor hypoxia as well as other physiological processes in a subject.
Inventors:
Groves and a cabin
Bao and Vagner
Bao and Vagner
Application Number:
JP2014510448A
Publication Date:
August 21, 2014
Filing Date:
May 09, 2012
Export Citation:
Assignee:
ビセン Medical treatment and in condominium lei テッド
International Classes:
A61K49/00; C09K11/06; G01N21/64; C07D401/14; C07D403/14; C07D417/14
Domestic Patent References:
| JP2008546757A | 2008-12-25 | |||
| JP2009507035A | 2009-02-19 | |||
| JP2009507108A | 2009-02-19 | |||
| JP2008546757A | 2008-12-25 | |||
| JP2009507035A | 2009-02-19 | |||
| JP2009507108A | 2009-02-19 |
Foreign References:
| WO2010121163A2 | 2010-10-21 | |||
| WO2010121163A2 | 2010-10-21 |
Other References:
JPN6016007270; ＤＵＢＯＩＳ， Ｌｕｄｗｉｇ ｅｔ ａｌ．: 'Ｉｍａｇｉｎｇ ｏｆ ＣＡ ＩＸ ｗｉｔｈ ｆｌｕｏｒｅｓｃｅｎｔ ｌａｂｅｌｌｅｄ ｓｕｌｆｏｎａｍｉｄｅｓ ｄｉｓｔｉｎｇｕｉｓｈｅｓ ｈｙｐｏｘｉｃａｎｄ （ｒｅ）-ｏｘｙｇｅｎａｔｅｄ ｃｅｌ' Ｒａｄｉｏｔｈｅｒａｐｙ ａｎｄ Ｏｎｃｏｌｏｇｙ Ｖｏｌ．９２， Ｎｏ．３, 2009, ｐ．４２３-４２８
JPN7016000434; ＢＲＵＢＡＫＥＲ， Ｋｒｉｓｔｅｎ Ｄ． ｅｔ ａｌ．: 'Ｌｏｃａｌｉｚａｔｉｏｎ ｏｆ Ｃａｒｂｏｎｉｃ Ａｎｈｙｄｒａｓｅ ｉｎ Ｌｉｖｉｎｇ Ｏｓｔｅｏｃｌａｓｔｓ ｗｉｔｈ Ｂｏｄｉｐｙ ５５８／５６８-ｍｏｄｉｆｉｅｄ Ａｃｅｔａｚｏｌａｍｉｄｅ，' Ｊｏｕｒｎａｌ ｏｆ Ｈｉｓｔｏｃｈｅｍｉｓｔｒｙ ＆ Ｃｙｔｏｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４７， Ｎｏ．４, 1999, ｐ．５４５-５５０
JPN6016007267; ＲＡＭＩ， Ｍａｒｏｕａｎ ｅｔ ａｌ．: 'Ｃａｒｂｏｎｉｃ ａｎｈｙｄｒａｓｅ ｉｎｈｉｂｉｔｏｒｓ： Ｇｄ（ＩＩＩ） ｃｏｍｐｌｅｘｅｓ ｏｆ ＤＯＴＡ- ａｎｄ ＴＥＴＡ-ｓｕｌｆｏｎａｍｉｄｅ ｃｏｎｊｕｇａｔｅｓ ｔａｒｇｅｔｉｎｇ' Ｎｅｗ Ｊｏｕｒｎａｌ ｏｆ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．３４, 2010, ｐ．２１３９-２１４４
JPN7016000434; ＢＲＵＢＡＫＥＲ， Ｋｒｉｓｔｅｎ Ｄ． ｅｔ ａｌ．: 'Ｌｏｃａｌｉｚａｔｉｏｎ ｏｆ Ｃａｒｂｏｎｉｃ Ａｎｈｙｄｒａｓｅ ｉｎ Ｌｉｖｉｎｇ Ｏｓｔｅｏｃｌａｓｔｓ ｗｉｔｈ Ｂｏｄｉｐｙ ５５８／５６８-ｍｏｄｉｆｉｅｄ Ａｃｅｔａｚｏｌａｍｉｄｅ，' Ｊｏｕｒｎａｌ ｏｆ Ｈｉｓｔｏｃｈｅｍｉｓｔｒｙ ＆ Ｃｙｔｏｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４７， Ｎｏ．４, 1999, ｐ．５４５-５５０
JPN6016007267; ＲＡＭＩ， Ｍａｒｏｕａｎ ｅｔ ａｌ．: 'Ｃａｒｂｏｎｉｃ ａｎｈｙｄｒａｓｅ ｉｎｈｉｂｉｔｏｒｓ： Ｇｄ（ＩＩＩ） ｃｏｍｐｌｅｘｅｓ ｏｆ ＤＯＴＡ- ａｎｄ ＴＥＴＡ-ｓｕｌｆｏｎａｍｉｄｅ ｃｏｎｊｕｇａｔｅｓ ｔａｒｇｅｔｉｎｇ' Ｎｅｗ Ｊｏｕｒｎａｌ ｏｆ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．３４, 2010, ｐ．２１３９-２１４４
JPN6016007270; ＤＵＢＯＩＳ， Ｌｕｄｗｉｇ ｅｔ ａｌ．: 'Ｉｍａｇｉｎｇ ｏｆ ＣＡ ＩＸ ｗｉｔｈ ｆｌｕｏｒｅｓｃｅｎｔ ｌａｂｅｌｌｅｄ ｓｕｌｆｏｎａｍｉｄｅｓ ｄｉｓｔｉｎｇｕｉｓｈｅｓ ｈｙｐｏｘｉｃａｎｄ （ｒｅ）-ｏｘｙｇｅｎａｔｅｄ ｃｅｌ' Ｒａｄｉｏｔｈｅｒａｐｙ ａｎｄ Ｏｎｃｏｌｏｇｙ Ｖｏｌ．９２， Ｎｏ．３, 2009, ｐ．４２３-４２８
JPN7016000434; ＢＲＵＢＡＫＥＲ， Ｋｒｉｓｔｅｎ Ｄ． ｅｔ ａｌ．: 'Ｌｏｃａｌｉｚａｔｉｏｎ ｏｆ Ｃａｒｂｏｎｉｃ Ａｎｈｙｄｒａｓｅ ｉｎ Ｌｉｖｉｎｇ Ｏｓｔｅｏｃｌａｓｔｓ ｗｉｔｈ Ｂｏｄｉｐｙ ５５８／５６８-ｍｏｄｉｆｉｅｄ Ａｃｅｔａｚｏｌａｍｉｄｅ，' Ｊｏｕｒｎａｌ ｏｆ Ｈｉｓｔｏｃｈｅｍｉｓｔｒｙ ＆ Ｃｙｔｏｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４７， Ｎｏ．４, 1999, ｐ．５４５-５５０
JPN6016007267; ＲＡＭＩ， Ｍａｒｏｕａｎ ｅｔ ａｌ．: 'Ｃａｒｂｏｎｉｃ ａｎｈｙｄｒａｓｅ ｉｎｈｉｂｉｔｏｒｓ： Ｇｄ（ＩＩＩ） ｃｏｍｐｌｅｘｅｓ ｏｆ ＤＯＴＡ- ａｎｄ ＴＥＴＡ-ｓｕｌｆｏｎａｍｉｄｅ ｃｏｎｊｕｇａｔｅｓ ｔａｒｇｅｔｉｎｇ' Ｎｅｗ Ｊｏｕｒｎａｌ ｏｆ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．３４, 2010, ｐ．２１３９-２１４４
JPN7016000434; ＢＲＵＢＡＫＥＲ， Ｋｒｉｓｔｅｎ Ｄ． ｅｔ ａｌ．: 'Ｌｏｃａｌｉｚａｔｉｏｎ ｏｆ Ｃａｒｂｏｎｉｃ Ａｎｈｙｄｒａｓｅ ｉｎ Ｌｉｖｉｎｇ Ｏｓｔｅｏｃｌａｓｔｓ ｗｉｔｈ Ｂｏｄｉｐｙ ５５８／５６８-ｍｏｄｉｆｉｅｄ Ａｃｅｔａｚｏｌａｍｉｄｅ，' Ｊｏｕｒｎａｌ ｏｆ Ｈｉｓｔｏｃｈｅｍｉｓｔｒｙ ＆ Ｃｙｔｏｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４７， Ｎｏ．４, 1999, ｐ．５４５-５５０
JPN6016007267; ＲＡＭＩ， Ｍａｒｏｕａｎ ｅｔ ａｌ．: 'Ｃａｒｂｏｎｉｃ ａｎｈｙｄｒａｓｅ ｉｎｈｉｂｉｔｏｒｓ： Ｇｄ（ＩＩＩ） ｃｏｍｐｌｅｘｅｓ ｏｆ ＤＯＴＡ- ａｎｄ ＴＥＴＡ-ｓｕｌｆｏｎａｍｉｄｅ ｃｏｎｊｕｇａｔｅｓ ｔａｒｇｅｔｉｎｇ' Ｎｅｗ Ｊｏｕｒｎａｌ ｏｆ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．３４, 2010, ｐ．２１３９-２１４４
JPN6016007270; ＤＵＢＯＩＳ， Ｌｕｄｗｉｇ ｅｔ ａｌ．: 'Ｉｍａｇｉｎｇ ｏｆ ＣＡ ＩＸ ｗｉｔｈ ｆｌｕｏｒｅｓｃｅｎｔ ｌａｂｅｌｌｅｄ ｓｕｌｆｏｎａｍｉｄｅｓ ｄｉｓｔｉｎｇｕｉｓｈｅｓ ｈｙｐｏｘｉｃａｎｄ （ｒｅ）-ｏｘｙｇｅｎａｔｅｄ ｃｅｌ' Ｒａｄｉｏｔｈｅｒａｐｙ ａｎｄ Ｏｎｃｏｌｏｇｙ Ｖｏｌ．９２， Ｎｏ．３, 2009, ｐ．４２３-４２８
Attorney, Agent or Firm:
Shusaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto