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Patent Searching and Data


Title:
高分子
Document Type and Number:
Japanese Patent JP2014520105
Kind Code:
A
Abstract:
A macromolecule includes i) a dendrimer with a core and at least one generation of lysine residue building units, the outermost generation of building units having surface amino groups, ii) a first terminal group covalently attached to a first surface amino group of a building unit, which includes a residue of docetaxel (DTX), and iii) a second terminal group covalently attached to a second surface amino group of a building unit, which includes a pharmacokinetic modifying agent. The pharmacokinetic modifying agent can be a polyethylene glycol (PEG). The first terminal group can be covalently attached to the surface amino group of the dendrimer through a diacid linker. The diacid linker can include a 2,2′-thiodiacetic acid residue. The diacid linker can form an ester bond with a hydroxyl group of the DTX and an amide bond with the surface amino group. A pharmaceutically acceptable salt of the macromolecule can be prepared.

Inventors:
David Owen
Brian Devlin Kelley
Peter Carreras
Application Number:
JP2014513858A
Publication Date:
August 21, 2014
Filing Date:
June 06, 2012
Export Citation:
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Assignee:
Star fame PTY Limited
International Classes:
A61K47/48; A61K31/337; A61K31/568; A61K31/7068; A61K38/00; A61K39/395; A61K45/00; A61K47/34; A61P5/26; A61P15/00; A61P35/00; A61P35/04; C07K5/103; C07K7/06
Foreign References:
WO2003055935A12003-07-10
Other References:
PHARMACEUTICAL RESEARCH, vol. 27(1), JPN6016010297, 2010, pages 161 - 174
今日の治療薬(2003年版), vol. 第25版, JPN6016010298, 15 February 2003 (2003-02-15), pages p.142,表1
Attorney, Agent or Firm:
Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Jitsuhiro