Title:
合成致死性および癌の治療
Document Type and Number:
Japanese Patent JP2014523440
Kind Code:
A
Abstract:
Described herein are compounds, compositions and methods for treatment of cancer. Also described are methods and uses for identifying subject with cancer that are suitable for treatment with the compounds, composition and methods are described herein. In one aspect of the present invention, there is provided a method of treating a subject having a cancer deficient in NMT2, comprising: administering to said subject an NMT inhibitor.
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Inventors:
リュク G ベルティオーム
エルワン Bauchant
Conga ニージュ マニカ Ann ペリンパナヤガム
Thuy Yap
エルワン Bauchant
Conga ニージュ マニカ Ann ペリンパナヤガム
Thuy Yap
Application Number:
JP2014520475A
Publication Date:
September 11, 2014
Filing Date:
July 23, 2012
Export Citation:
Assignee:
パシレックス Pharmaceuticals, Incorporated
International Classes:
A61K45/00; A61K31/20; A61K31/28; A61K31/415; A61K31/7105; A61K31/713; A61K39/395; A61K48/00; A61P35/00; A61P35/02; A61P43/00; C07K16/00; C12N9/99; C12N15/09
Domestic Patent References:
| JPH04210916A | 1992-08-03 | |||
| JP2007520557A | 2007-07-26 |
Foreign References:
| WO2008076965A1 | 2008-06-26 | |||
| WO2010026365A1 | 2010-03-11 | |||
| US20100068731A1 | 2010-03-18 |
Other References:
DUCKER CE, ET AL.: "Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and", MOLECULAR CANCER RESEARCH, vol. 3, no. 8, JPN6016016826, August 2005 (2005-08-01), pages 463 - 476
BHANDARKAR SS, ET AL.: "Tris (dibenzylideneacetone) dipalladium, a N-myristoyltransferase-1 inhibitor, is effective against", CLINICAL CANCER RESEARCH, vol. 14, no. 18, JPN6016016829, 15 September 2008 (2008-09-15), pages 5743 - 5748, XP055142988, DOI: doi:10.1158/1078-0432.CCR-08-0405
SELVAKUMAR P, ET AL.: "N-myristoyltransferase 2 expression in human colon cancer: cross-talk between the calpain and caspas", FEBS LETTERS, vol. 580, no. 8, JPN6016016833, 2006, pages 2021 - 2026, XP028030344, DOI: doi:10.1016/j.febslet.2006.02.076
SHRIVASTAV A, ET AL.: "Overexpression of Akt/PKB modulates N-myristoyltransferase activity in cancer cells", JOURNAL OF PATHOLOGY, vol. 218, no. 3, JPN6016016836, 5 March 2009 (2009-03-05), pages 391 - 398
LU Y, ET AL.: "Expression of N-myristoyltransferase in human brain tumors", NEUROCHEMICAL RESEARCH, vol. 30, no. 1, JPN6016016838, January 2005 (2005-01-01), pages 9 - 13, XP019289731
メルクマニュアル 第１８版 日本語版, JPN6017012495, 25 April 2007 (2007-04-25), pages ｐ．１１７７−１１８６
BHANDARKAR SS, ET AL.: "Tris (dibenzylideneacetone) dipalladium, a N-myristoyltransferase-1 inhibitor, is effective against", CLINICAL CANCER RESEARCH, vol. 14, no. 18, JPN6016016829, 15 September 2008 (2008-09-15), pages 5743 - 5748, XP055142988, DOI: doi:10.1158/1078-0432.CCR-08-0405
SELVAKUMAR P, ET AL.: "N-myristoyltransferase 2 expression in human colon cancer: cross-talk between the calpain and caspas", FEBS LETTERS, vol. 580, no. 8, JPN6016016833, 2006, pages 2021 - 2026, XP028030344, DOI: doi:10.1016/j.febslet.2006.02.076
SHRIVASTAV A, ET AL.: "Overexpression of Akt/PKB modulates N-myristoyltransferase activity in cancer cells", JOURNAL OF PATHOLOGY, vol. 218, no. 3, JPN6016016836, 5 March 2009 (2009-03-05), pages 391 - 398
LU Y, ET AL.: "Expression of N-myristoyltransferase in human brain tumors", NEUROCHEMICAL RESEARCH, vol. 30, no. 1, JPN6016016838, January 2005 (2005-01-01), pages 9 - 13, XP019289731
メルクマニュアル 第１８版 日本語版, JPN6017012495, 25 April 2007 (2007-04-25), pages ｐ．１１７７−１１８６
Attorney, Agent or Firm:
Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Jitsuhiro
Masatake Shiga
Takashi Watanabe
Shinya Jitsuhiro