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Title:
血小板産生のための巨核球前駆細胞
Document Type and Number:
Japanese Patent JP2014523741
Kind Code:
A
Abstract:
Provided herein are methods of generating megakaryocyte lineage cells from hematopoietic stem cells in the absence of feeder cells and serum. The megakaryocyte progenitor cells (MKPs) generated as described result in rapid production of significant numbers of platelets when administered in vivo.

Inventors:
Car sunki ホルジャー
チャナヌクル チャナワン
パヌガンティ スワプナ
Application Number:
JP2014519073A
Publication Date:
September 18, 2014
Filing Date:
July 06, 2012
Export Citation:
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Assignee:
Ceret Lunt Therapeutics In condominium lei テッド
International Classes:
C12N5/0789; A61K35/12; A61K35/28; A61P7/04
Domestic Patent References:
JP2005538720A2005-12-22
JP2003534257A2003-11-18
JPH09505462A1997-06-03
Foreign References:
US20070072295A12007-03-29
Other References:
PLATELETS, vol. 12, no. 6, JPN6016025631, 2001, pages 325 - 332, ISSN: 0003354848
J. EXP. HEMATOLOGY, vol. 14, no. 4, JPN6016025632, 2006, pages 835 - 839, ISSN: 0003354849
BLOOD, vol. 91, no. 11, JPN6016025634, 1998, pages 4118 - 4126, ISSN: 0003354850
BRITISH J. HAEMATOL., vol. 99, JPN6016025636, 1997, pages 509 - 516, ISSN: 0003354851
EXP. HAEMATOL., vol. 30, JPN6016025638, 2002, pages 1373 - 1380, ISSN: 0003354852
Attorney, Agent or Firm:
Spring water Original aim
Masao Haruna
Hirotaka Yamaguchi
Shun Osakabe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shin-ichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto



 
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