Title:
選択的グリコシダーゼ阻害剤およびその使用
Document Type and Number:
Japanese Patent JP2014524911
Kind Code:
A
Abstract:
The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
Inventors:
Li and ton * シュアン
Game マケー and Ernest Jay.
ヴォカドゥロ and David Jay.
Jo and ユアンシ
Jeu and John Bao
Cell ニック and Harold G.
Game マケー and Ernest Jay.
ヴォカドゥロ and David Jay.
Jo and ユアンシ
Jeu and John Bao
Cell ニック and Harold G.
Application Number:
JP2014517357A
Publication Date:
September 25, 2014
Filing Date:
June 27, 2012
Export Citation:
Assignee:
アレクトス Therapeutics, Incorporated
Merck sharp and dome corporation Merck Sharp & Dohme Corp.
Merck sharp and dome corporation Merck Sharp & Dohme Corp.
International Classes:
C07H9/06; A61K31/7056; A61P1/04; A61P5/14; A61P9/00; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P21/00; A61P21/04; A61P25/00; A61P25/02; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/28; A61P27/06; A61P29/00; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C12N9/99
Domestic Patent References:
| JP2010501598A | 2010-01-21 | |||
| JP5861194B2 | 2016-02-16 |
Attorney, Agent or Firm:
Shusaku Yamamoto
Natsuki Morishita
Natsuki Morishita