タンパク質連結用クリックケミストリーハンドルを設置するためのソルターゼの使用 - Whitehead institute Fau biomedical research Whitehead Institute for Biomedical Research

Title:

タンパク質連結用クリックケミストリーハンドルを設置するためのソルターゼの使用

Document Type and Number:

Japanese Patent JP2014525904

Kind Code:

A

Abstract:

Methods and reagents for the installation of click chemistry handles on target proteins are provided, as well as modified proteins comprising click chemistry handles. Further, chimeric proteins, for example, bi-specific antibodies, that comprise two proteins conjugated via click chemistry, as well as methods for their generation and use are disclosed herein.

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Inventors:

プローグ, ヒディー El
Witte, Martin Dee
ヨダー, Nicolas See

Application Number:

JP2014519003A

Publication Date:

October 02, 2014

Filing Date:

June 28, 2012

Export Citation:

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Assignee:

Whitehead institute Fau biomedical research Whitehead Institute for Biomedical Research

International Classes:

C07K19/00; C07K16/46; C12P21/02; C12P21/08; C12N15/09

Domestic Patent References:

JP2009189325A

2009-08-27

Other References:

JPN6016019094; Ｒａｎｇａｎａｔｈ　Ｐａｒｔｈａｓａｒａｔｈｙ　ｅｔ　ａｌ．: 'Ｓｏｒｔａｓｅ　Ａ　ａｓ　ａ　Ｎｏｖｅｌ　Ｍｏｌｅｃｕｌａｒ　"Ｓｔａｐｌｅｒ"　ｆｏｒ　Ｓｅｑｕｅｎｃｅ-Ｓｐｅｃｉｆｉｃ　Ｐｒｏｔｅｉｎ　Ｃｏｎｊｕｇａｔｉｏｎ' Ｂｉｏｃｏｎｊｕｇａｔｅ　ＣｈｅｍｉｓｔｒｙＶｏｌ．１８, 2007, ｐｐ．４６９-４７６
JPN6016019095; Ｄａｖｉｄ　Ａ．　Ｌｅｖａｒｙ　ｅｔ　ａｌ．: 'Ｐｒｏｔｅｉｎ-Ｐｒｏｔｅｉｎ　Ｆｕｓｉｏｎ　Ｃａｔａｌｙｚｅｄ　ｂｙ　Ｓｏｒｔａｓｅ　Ａ' ＰＬＯＳ　ＯＮＥＶｏｌ．６，　Ｉｓｓｕｅ　４, 201104, ｅ１８３４２
JPN6016019098; Ｃｈｒｉｓｔｉａｎ　Ｐ．　Ｒ．　Ｈａｃｋｅｎｂｅｒｇｅｒ　ｅｔ　ａｌ．: 'Ｃｈｅｍｏｓｅｌｅｃｔｉｖｅ　Ｌｉｇａｔｉｏｎ　ａｎｄ　Ｍｏｄｉｆｉｃａｔｉｏｎ　Ｓｔｒａｔｅｇｉｅｓ　ｆｏｒ　Ｐｅｐｔｉｄｅｓ　ａｎｄ　Ｐｒｏｔｅｉｎｓ' Ａｎｇｅｗａｎｔｅ　Ｃｈｅｍｉｅ　Ｉｎｔｅｒｎａｔｉｏｎａｌ　ＥｄｉｔｉｏｎＶｏｌ．４７, 2008, ｐｐ．１００３０-１００７４

Attorney, Agent or Firm:

Seiji Yanagida
Sakuma 剛

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