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Title:
TAIL VARIANT OF OXIDATION-REDUCTION ACTIVITY THERAPEUTIC AGENT FOR THERAPY OF MITOCHONDRIAL DISEASE AND RELATED CONDITION AND FOR ADJUSTMENT OF ENERGY BIOMARKER
Document Type and Number:
Japanese Patent JP2015078224
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a compound useful for therapy or suppression of diseases due to mitochondrial diseases and for adjustment of an energy biomarker in a subject.SOLUTION: A method of treating a mitochondrial disease, adjusting 1 or more energy biomarkers, normalizing 1 or more energy biomarkers, or enhancing 1 or more energy biomarkers comprises a step of administering a therapeutically effective amount of a hydroquinone compound represented by the formula or an oxidized form thereof (a quinone compound) to a subject (Rto Rare each independently a C1 to 4 alkyl or the like; and Ris a C1 to 20 alkyl, alkenyl or the like.)

Inventors:
MILLER GUY M
HECHT SIDNEY M
Application Number:
JP2014254928A
Publication Date:
April 23, 2015
Filing Date:
December 17, 2014
Export Citation:
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Assignee:
EDISON PHARMACEUTICALS INC
International Classes:
A61K31/05; A61K31/122; A61P3/10; A61P9/00; A61P15/12; A61P21/02; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P27/02; A61P35/00; A61P43/00; C07C39/08; C07C50/02; C07C50/06
Domestic Patent References:
JPS6056902A1985-04-02
JPS6056902A1985-04-02
Foreign References:
US20030119054A12003-06-26
US20050186518A12005-08-25
UST917001I41973-12-04
US2398418A1946-04-16
US20030119054A12003-06-26
US20050186518A12005-08-25
UST917001I41973-12-04
US2398418A1946-04-16
Other References:
JPN6012016673; Soll HJ and Oettmeier W: 'Inhibitor binding and displacement in plastoquinone depleted chloroplasts' Adv. Photosynth. Res. Proc. Int. Congr. Photosynth., 6th Vol.4, 1983, pp.5-8
JPN5008014488; MYAGKOV,I.V.: KOLLOIDNYI ZHURNAL V47 N5, 1985, P967-971
JPN6012016675; Shi JL et al.: 'Hydrophobic Acceleration of Electron Transfer Processes.' J Org Chem. Vol.61 no.14, 19960712, pp.4698-4702
JPN5008014486; SPOYALOV,A.P.: JOURNAL OF THE CHEMICAL SOCIETY,PERKIN TRANSACTIONS 2 N9, 1992, P1519-1524
JPN6012016678; Lianquan G et al.: 'Synthesis and inhibitory activity of bromoquinone derivatives' Tetrahedron Vol.46 no.9, 1990, pp.3199-3210
JPN6012016680; Cressman HWJ and Thirtle JR: 'One-Step Synthesis of Polyalkyl-2-iodo-p-benzoquinones' J. Org. Chem. Vol.31 no.4, 1966, pp.1279-1281
JPN6012016685; Pileni MP: 'Zinc-porphyrin sensitized reduction of simple and functional quinones in vesicle systems' Chemical Physics Letters Vol.71 no.2, 19800415, pp.317-321
JPN6012016682; Gu LQ et al.: 'Effect of substituents of the benzoquinone ring on electron-transfer activities of ubiquinone deriva' Biochim Biophys Acta. Vol.1015 no.3, 19900222, pp.482-492
JPN6013035858; Walter L et al.: 'Three classes of ubiquinone analogs regulate the mitochondrial permeability transition pore through' J Biol Chem Vol.275 No.38, 20000922, pp.29521-29527
JPN6013035859; Gu L et al.: 'Synthesis, oxidation-reduction potentials and biological activity of 1,4-benzoquinone derivatives' Youji Huaxue Vol.11 No.5, 1991, pp.481-487
JPN6012016673; Soll HJ and Oettmeier W: 'Inhibitor binding and displacement in plastoquinone depleted chloroplasts' Adv. Photosynth. Res. Proc. Int. Congr. Photosynth., 6th Vol.4, 1983, pp.5-8
JPN5008014488; MYAGKOV,I.V.: KOLLOIDNYI ZHURNAL V47 N5, 1985, abstract
JPN6012016675; Shi JL et al.: 'Hydrophobic Acceleration of Electron Transfer Processes.' J Org Chem. Vol.61 no.14, 19960712, pp.4698-4702
JPN5008014486; SPOYALOV,A.P.: JOURNAL OF THE CHEMICAL SOCIETY,PERKIN TRANSACTIONS 2 N9, 1992, abstract
JPN6012016678; Lianquan G et al.: 'Synthesis and inhibitory activity of bromoquinone derivatives' Tetrahedron Vol.46 no.9, 1990, pp.3199-3210
JPN6012016680; Cressman HWJ and Thirtle JR: 'One-Step Synthesis of Polyalkyl-2-iodo-p-benzoquinones' J. Org. Chem. Vol.31 no.4, 1966, pp.1279-1281
JPN6012016685; Pileni MP: 'Zinc-porphyrin sensitized reduction of simple and functional quinones in vesicle systems' Chemical Physics Letters Vol.71 no.2, 19800415, pp.317-321
JPN6012016682; Gu LQ et al.: 'Effect of substituents of the benzoquinone ring on electron-transfer activities of ubiquinone deriva' Biochim Biophys Acta. Vol.1015 no.3, 19900222, pp.482-492
JPN6013035858; Walter L et al.: 'Three classes of ubiquinone analogs regulate the mitochondrial permeability transition pore through' J Biol Chem Vol.275 No.38, 20000922, pp.29521-29527
JPN6013035859; Gu L et al.: 'Synthesis, oxidation-reduction potentials and biological activity of 1,4-benzoquinone derivatives' Youji Huaxue Vol.11 No.5, 1991, pp.481-487
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita