Title:
PERFLUOROALKYLATION REACTION OF AROMATIC COMPOUND
Document Type and Number:
Japanese Patent JP2015086221
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a novel perfluoroalkylation reaction of an aromatic compound having a perfluoroalkyl group or a fluorophenyl group, which exhibits a high yield and is convenient, and which can be applicable to a wide range of compounds.SOLUTION: In a perfluoroalkylation reaction, a fluorine-containing compound represented by formula (3) is obtained by making a compound represented by formula (1) and a perfluoroalkyl iodide represented by formula X-Rand the like react with each other in the presence of dialkylzinc and a copper catalyst and in an aprotic polar solvent (A is a substituted or unsubstituted aryl or heteroaryl group; X is Br or I; and Ris a phenyl group having a 1-20C perfluoroalkyl group or 1-5 fluoro groups).
Inventors:
UCHIYAMA NAONOBU
HIRANO KEIICHI
HIRANO KEIICHI
Application Number:
JP2014194243A
Publication Date:
May 07, 2015
Filing Date:
September 24, 2014
Export Citation:
Assignee:
UNIV TOKYO
International Classes:
C07B39/00; C07C17/269; C07C22/08; C07C41/30; C07C43/225; C07C43/29; C07C45/68; C07C46/00; C07C49/813; C07C50/16; C07C67/293; C07C67/343; C07C69/24; C07C69/76; C07C69/773; C07C231/12; C07C233/65; C07C253/30; C07C255/50; C07C255/51; C07D209/10; C07D213/61; C07D215/12; C07D239/54; C07D241/12; C07D263/56; C07D277/64; C07D333/38; C07D473/12; C07F5/04; C07F7/18
Domestic Patent References:
| JPS5011891B1 | 1975-05-07 | |||
| JPH0215084A | 1990-01-18 | |||
| JPH049342A | 1992-01-14 | |||
| JPS5011891B1 | 1975-05-07 | |||
| JPH0215084A | 1990-01-18 | |||
| JPH049342A | 1992-01-14 |
Foreign References:
| US20090118529A1 | 2009-05-07 | |||
| US20090118529A1 | 2009-05-07 |
Other References:
"Copper-Catalyzed Arylation of 1H-Perfluoroalkanes", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 2011, 133 (24), pp 9286-9289, JPN6018023561, 2011
"Generation of arylzinc reagents through an iodine-zinc exchange reaction", NEW JOURNAL OF CHEMISTRY, vol. Vol. 34, No. 8, P1700-1706, JPN6018023563, 2010
"Copper-Catalyzed Arylation of 1H-Perfluoroalkanes", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 2011, 133 (24), pp 9286-9289, JPN6018023561, 2011
"Generation of arylzinc reagents through an iodine-zinc exchange reaction", NEW JOURNAL OF CHEMISTRY, vol. Vol. 34, No. 8, P1700-1706, JPN6018023563, 2010
"Generation of arylzinc reagents through an iodine-zinc exchange reaction", NEW JOURNAL OF CHEMISTRY, vol. Vol. 34, No. 8, P1700-1706, JPN6018023563, 2010
"Copper-Catalyzed Arylation of 1H-Perfluoroalkanes", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 2011, 133 (24), pp 9286-9289, JPN6018023561, 2011
"Generation of arylzinc reagents through an iodine-zinc exchange reaction", NEW JOURNAL OF CHEMISTRY, vol. Vol. 34, No. 8, P1700-1706, JPN6018023563, 2010
Attorney, Agent or Firm:
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Yoshikazu Iwase
Yasufumi Shiroyama
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Yoshikazu Iwase
Yasufumi Shiroyama
Previous Patent: JP2015086220
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