Title:
脂漏性角化症を治療および予防するための薬剤および方法
Document Type and Number:
Japanese Patent JP2015520737
Kind Code:
A
Abstract:
脂漏性角化症細胞を単離してエクスビボで培養するための方法およびアッセイを提供する。また、培養した脂漏性角化症細胞を用いるスクリーニングアッセイ、および対象において脂漏性角化症を治療するための方法も提供する。
Inventors:
Mandy Nova Anna Ai.
Lee Sam W.
Neil Victor A.
Lee Sam W.
Neil Victor A.
Application Number:
JP2015509171A
Publication Date:
July 23, 2015
Filing Date:
April 26, 2013
Export Citation:
Assignee:
The General Hospital Corporation
International Classes:
A61K45/00; A61K31/4439; A61K31/4545; A61K31/7105; A61K48/00; A61P17/00; A61P17/08; A61P17/12; A61P43/00; C12N5/071; C12Q1/02; G01N33/15; G01N33/50; G01N33/53
Domestic Patent References:
| JP2007530705A | 2007-11-01 |
Foreign References:
| WO2008121261A2 | 2008-10-09 |
Other References:
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2011, VOL.131, P.1583-1586, JPN6017005527
CHAN,T.O. ET AL.: "Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity.", PROC. NATL. ACAD. SCI. USA, vol. 108, no. 46, JPN6017037380, 15 November 2011 (2011-11-15), pages E1120-7
ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ, vol. Ｖｏｌ．５０，Ｎｏ．１０, JPN6018037364, 2007, pages ｐ２２９３−２２９６
ＩＮＴＥＲＮＡＴＩＯＮＡＬ ＪＯＵＲＮＡＬ ＯＦ ＯＮＣＯＬＯＧＹ, vol. Ｖｏｌ．４８，Ｎｏ．３, JPN6018037367, 2016, pages ｐ８６９−８８５
CHAN,T.O. ET AL.: "Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity.", PROC. NATL. ACAD. SCI. USA, vol. 108, no. 46, JPN6017037380, 15 November 2011 (2011-11-15), pages E1120-7
ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ, vol. Ｖｏｌ．５０，Ｎｏ．１０, JPN6018037364, 2007, pages ｐ２２９３−２２９６
ＩＮＴＥＲＮＡＴＩＯＮＡＬ ＪＯＵＲＮＡＬ ＯＦ ＯＮＣＯＬＯＧＹ, vol. Ｖｏｌ．４８，Ｎｏ．３, JPN6018037367, 2016, pages ｐ８６９−８８５
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto