Title:
ガンを予防および治療するためのマレイミド誘導体の使用
Document Type and Number:
Japanese Patent JP2016508962
Kind Code:
A
Abstract:
本発明は、ガンの治療および／または予防のための方法での使用のための、式（Ｉ）【化１】の化合物、薬学的に許容できるその塩、その水和物、その溶媒和物、その代謝物またはそのプロドラッグに関し；ここで、Ｘは、Ｎ−Ｒ１、ＯおよびＳからなる群から選択され；Ｒ１は、アルキル、シクロアルキル、アリール、アリールアルキルおよび水素からなる群から選択され；Ｒ２は、インドリル、置換インドリル、アザインドリルおよび置換アザインドリルからなる群から選択され；および、Ｒ３は、アリール、置換アリール、非置換ヘテロアリール、ヘテロシクリルおよび置換ヘテロシクリルからなる群から選択される。
Inventors:
Beller Machias
Lucas Jean
Fleck Moritz
Junghans Christian
Rolfus Aunt
Pewth-Dafchan Ana Hit
Lucas Jean
Fleck Moritz
Junghans Christian
Rolfus Aunt
Pewth-Dafchan Ana Hit
Application Number:
JP2015545699A
Publication Date:
March 24, 2016
Filing Date:
December 10, 2013
Export Citation:
Assignee:
Saint Jean Age
International Classes:
C07D401/14; A61K31/404; A61K31/437; A61K31/4439; A61K39/395; A61K45/00; A61P35/00; A61P35/04; C07D403/04; C07D403/14; C07D405/04; C07D409/14; C07D471/04
Domestic Patent References:
| JP2005531607A | 2005-10-20 | |||
| JP2008523009A | 2008-07-03 | |||
| JPH01233281A | 1989-09-19 | |||
| JP2011506288A | 2011-03-03 | |||
| JP2004513168A | 2004-04-30 | |||
| JP2005529918A | 2005-10-06 | |||
| JP2016504299A | 2016-02-12 |
Foreign References:
| WO2011073092A1 | 2011-06-23 | |||
| WO1999042100A1 | 1999-08-26 | |||
| WO2007008514A2 | 2007-01-18 | |||
| WO2011073091A1 | 2011-06-23 |
Other References:
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HILLIARD TYVETTE S, ANTI-CANCER DRUGS, vol. V22 N10, JPN5016000260, November 2011 (2011-11-01), pages 78 - 985
SONG EMMA Y, EXPERIMENTAL HEMATOLOGY, vol. V38 N10, JPN5016000371, 1 October 2010 (2010-10-01), US, pages 08 - 921
SCHMOELE ANNE-CAROLINE, BIOORGANIC & MEDICINAL CHEMISTRY, vol. V18 N18, JPN5016000373, 15 September 2010 (2010-09-15), GB, pages 785 - 6795
KATOH MIHO, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. V15 N12, JPN5016000374, 15 June 2005 (2005-06-15), NL, pages 109 - 3113
XU GUI-QING: "SYNTHESIS AND CYTOTOXICITY OF INDOLOPYRROLEMALEIMIDES", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. V55 N9, JPN5016000375, 1 September 2007 (2007-09-01), JP, pages 302 - 1307
HEIDEL FLORIAN H: "3,4-DIARYLMALEIMIDES - A NOVEL CLASS 以下省略", ANNALS OF HEMATOLOGY, vol. V91 N3, JPN5016000257, March 2012 (2012-03-01), pages 31 - 344
SHORUNOV S V, RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, vol. V42 N10, JPN5016000380, 1 October 2006 (2006-10-01), MO, pages 490 - 1497
GANSER CHRISTOPHER, JOURNAL OF MEDICINAL CHEMISTRY, vol. V55 N22, JPN5016000258, 26 November 2012 (2012-11-26), pages 531 - 9540
PEIFER CHRISTIAN: "DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF NOVEL 以下省略", JOURNAL OF MEDICINAL CHEMISTRY, vol. V51, JPN5016000262, 1 January 2008 (2008-01-01), US, pages 814 - 3824
HILLIARD TYVETTE S, ANTI-CANCER DRUGS, vol. V22 N10, JPN5016000260, November 2011 (2011-11-01), pages 78 - 985
Attorney, Agent or Firm:
Masahiro Nanjo
Ayako Seta
Koichiro Inami
Hidetoshi Hara
Ayako Seta
Koichiro Inami
Hidetoshi Hara