Title:
癌を治療するための新規な化合物
Document Type and Number:
Japanese Patent JP2016521737
Kind Code:
A
Abstract:
本発明は、Mps−1キナーゼの阻害効果を示す新規な化合物、前記化合物を調製する方法、前記化合物を含む医薬組成物および組合せ、疾患を治療または予防するための医薬組成物を製造するための前記化合物の使用、ならびに前記化合物の調製に有用な中間体化合物に関する。
Inventors:
Volker Schulze
Hartmut Shirok
Dirk Kozemund
Hans Bream
Benjamin Birder
Wolf Behma
Antie Margru Wengner
Gerhard Giemeister
Philip Linau
Detlef Stecchito
Ulrich Lucking
Andreas Shall
Hartmut Shirok
Dirk Kozemund
Hans Bream
Benjamin Birder
Wolf Behma
Antie Margru Wengner
Gerhard Giemeister
Philip Linau
Detlef Stecchito
Ulrich Lucking
Andreas Shall
Application Number:
JP2016518921A
Publication Date:
July 25, 2016
Filing Date:
June 04, 2014
Export Citation:
Assignee:
Bayer Pharma Actien Gezelshaft
International Classes:
C07D277/82; A61K31/136; A61K31/166; A61K31/167; A61K31/198; A61K31/282; A61K31/337; A61K31/427; A61K31/428; A61K31/437; A61K31/444; A61K31/475; A61K31/4985; A61K31/5025; A61K31/513; A61K31/522; A61K31/5377; A61K31/565; A61K31/57; A61K31/573; A61K31/675; A61K31/69; A61K31/704; A61K31/7068; A61K31/7076; A61K33/24; A61K38/00; A61K39/395; A61P29/00; A61P35/00; A61P35/02; A61P35/04; A61P37/02; A61P43/00; C07D471/04; C07D487/04
Domestic Patent References:
| JP2011529086A | 2011-12-01 | |||
| JP2015509512A | 2015-03-30 |
Foreign References:
| WO2012143329A1 | 2012-10-26 | |||
| WO2012080230A1 | 2012-06-21 | |||
| WO2012136531A1 | 2012-10-11 | |||
| WO2011161159A1 | 2011-12-29 | |||
| WO2009133127A1 | 2009-11-05 | |||
| WO2009128520A1 | 2009-10-22 | |||
| WO2010007100A1 | 2010-01-21 | |||
| WO2011110575A1 | 2011-09-15 |
Other References:
URICH,R. ET AL: "De Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding Frag", ACS CHEMICAL BIOLOGY, vol. 8, no. 5, JPN5016006703, 27 March 2013 (2013-03-27), pages 1044 - 1052, XP055144440, ISSN: 0003986201, DOI: 10.1021/cb300729y
GIORDANETTO,F. ET AL: "Discovery of novel class 1 phosphatidylinositide 3-kinases (PI3K) fragment inhibitors through struct", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, no. 2, JPN6018030109, 24 November 2010 (2010-11-24), pages 829 - 835, XP027593568, ISSN: 0003986202, DOI: 10.1016/j.bmcl.2010.11.087
HONG,S. ET AL: "Discovery of New Benzothiazole-Based Inhibitors of Breakpoint Cluster Region-Abelson Kinase Includin", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, no. 9, JPN6018030112, 19 April 2013 (2013-04-19), pages 3531 - 3545, XP055855402, ISSN: 0003851979, DOI: 10.1021/jm301891t
GIORDANETTO,F. ET AL: "Discovery of novel class 1 phosphatidylinositide 3-kinases (PI3K) fragment inhibitors through struct", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, no. 2, JPN6018030109, 24 November 2010 (2010-11-24), pages 829 - 835, XP027593568, ISSN: 0003986202, DOI: 10.1016/j.bmcl.2010.11.087
HONG,S. ET AL: "Discovery of New Benzothiazole-Based Inhibitors of Breakpoint Cluster Region-Abelson Kinase Includin", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, no. 9, JPN6018030112, 19 April 2013 (2013-04-19), pages 3531 - 3545, XP055855402, ISSN: 0003851979, DOI: 10.1021/jm301891t
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe
Shinya Mitsuhiro
Tatsuhiko Abe