Title:
多発性硬化症を治療するためのレチノイン酸関連核内オーファン受容体拮抗剤である置換された２，３−ジヒドロ−１Ｈ−インデン−１−オン
Document Type and Number:
Japanese Patent JP2016531146
Kind Code:
A
Abstract:
【解決手段】本発明は、化合物、その合成、及び、レチノイン酸関連核内オーファン受容体γｔ（ＲＯＲγｔ）／ＲＯＲγの拮抗剤、逆作動剤、調節剤、及び／又は阻害剤としてのその利用に関する。本発明の化合物は、（ＲＯＲγｔ）／ＲＯＲγの活性の調節、及び、（ＲＯＲγｔ）／ＲＯＲγにより媒介される疾患又は状態、例えば、多発性硬化症（ＭＳ）、関節リウマチ（ＲＡ）、炎症性大腸炎、乾癬、ＣＯＰＤ、痛み、肥満、糖尿病、脂質異常症、骨粗鬆症、喘息、神経変性疾患、及び癌などのヒト自己免疫疾患の免疫病理に関連する病態などの治療のために有用である。【選択図】図１
Inventors:
Van Cai Alapati, Hali Prasad
Yarlam Lady, Venkata Krishna Lady
Yarlam Lady, Venkata Krishna Lady
Application Number:
JP2016542000A
Publication Date:
October 06, 2016
Filing Date:
August 28, 2014
Export Citation:
Assignee:
Arlene Pharmaceuticals LLC
International Classes:
C07C323/22; A61K31/122; A61K31/255; A61K31/445; A61K31/4468; A61K31/451; A61K31/4545; A61K31/495; A61K31/496; A61K31/5375; A61K31/5377; A61P1/04; A61P3/04; A61P3/06; A61P3/10; A61P11/00; A61P11/06; A61P17/06; A61P19/02; A61P19/10; A61P25/00; A61P25/04; A61P25/28; A61P29/00; A61P35/00; A61P35/02; A61P37/00; A61P43/00; C07D211/14; C07D211/32; C07D211/38; C07D211/58; C07D213/50; C07D213/61; C07D231/12; C07D241/04; C07D277/42; C07D295/116; C07D401/10; C07D401/12
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Foreign References:
| WO2003061658A1 | 2003-07-31 |
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HAWORTH, I. R. D. ET AL.: "Galloflavin", JOURNAL OF THE CHEMICAL SOCIETY, JPN7017000333, 1952, pages 1583 - 1589, ISSN: 0003491847
YAMAMURA, SHIRO ET AL.: "Studies on the structure-activity relationship of adrenergic β-mimetic benzylamine derivatives. IV", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 26, no. 12, JPN7017000334, 1978, pages 3613 - 3623, XP009046709, ISSN: 0003491848
Attorney, Agent or Firm:
Sakaki Morishita