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Title:
PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING LUPUS NEPHRITIS AND BIOMARKER FOR LUPUS NEPHRITIS
Document Type and Number:
Japanese Patent JP2018150272
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a composition and a method contributing to the treatment, prevention or diagnosis of lupus nephritis.SOLUTION: Provided are: a pharmaceutical composition for the treatment or prevention of lupus nephritis comprising a RAGE aptamer is provided; a method of diagnosing lupus nephritis comprising measuring the concentration of RAGE in urine collected from a subject; and a composition or kit for diagnosing lupus nephritis comprising a reagent for detecting RAGE. The use of RAGE as a biomarker for lupus nephritis is also provided.SELECTED DRAWING: Figure 11

Inventors:
TAGUCHI AKIMASA
FUKAMI KEI
Application Number:
JP2017047168A
Publication Date:
September 27, 2018
Filing Date:
March 13, 2017
Export Citation:
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Assignee:
UNIV KURUME
International Classes:
A61K45/00; A61K31/711; A61P13/12; A61P37/02
Domestic Patent References:
JP2016079184A2016-05-16
JP2009517404A2009-04-30
JP2015146809A2015-08-20
Foreign References:
KR20130083861A2013-07-23
Other References:
NAT REV NEPHROL., 2010, VOL.6, P.352-360, JPN6020033443, ISSN: 0004467526
CURR OPIN NEPHROL HYPERTENS., 2015, VOL.24 NO.1, P.54-60, JPN6020033447, ISSN: 0004467527
ACTA UNIVERSITATIS MEDICINALIS ANHUI, 2015, VOL.50 NO.4, P.533-537, JPN6020033448, ISSN: 0004467528
ARTHRITIS & RHEUMATISM, 2011, VOL.63, P.S1020(ABSTRACT NO.2597), JPN6020033451, ISSN: 0004467529
NAT IMMUNOL., 2007, VOL.8 NO.5, P.487-496, JPN6020033454, ISSN: 0004467530
Attorney, Agent or Firm:
Takuji Yamada
Aoyama Aoi
Michiko Matsutani
Sakurai Yoko