Title:
抗腫瘍活性を有する不斉ビス−アクリジンおよびその使用
Document Type and Number:
Japanese Patent JP2018509453
Kind Code:
A
Abstract:
抗腫瘍活性を有する新規の不斉ビス−アクリジンを開示する。これらの化合物は、医薬に、具体的には新生物の治療または予防に有用である。
Inventors:
Konopa, Jesi Kazimierz
Kholovska, Barbara
Parshkovich, Eva Maria
Borova-Mazguy, Barbara
Augustin, Eva Ana
Skalska, Anna
Maserska, Sofia
Kholovska, Barbara
Parshkovich, Eva Maria
Borova-Mazguy, Barbara
Augustin, Eva Ana
Skalska, Anna
Maserska, Sofia
Application Number:
JP2017550248A
Publication Date:
April 05, 2018
Filing Date:
March 17, 2016
Export Citation:
Assignee:
Politechnika Gdanska
International Classes:
C07D219/12; A61K31/473; A61K31/4745; A61K31/496; A61P1/18; A61P35/00; A61P43/00; C07D471/06
Domestic Patent References:
| JP2000508662A | 2000-07-11 | |||
| JPS56166176A | 1981-12-21 | |||
| JP2001512104A | 2001-08-21 | |||
| JPS52102282A | 1977-08-27 |
Foreign References:
| WO1998057956A1 | 1998-12-23 | |||
| WO2011051950A1 | 2011-05-05 | |||
| CN104230805A | 2014-12-24 | |||
| US5886185A | 1999-03-23 |
Other References:
CHOLODY, WIESLAW M.; KOSAKOWSKA-CHOLODY, TERESA; HOLLINGSHEAD, MELINDA G.; HARIPRAKASHA, HUMCHA K.;: "A New Synthetic Agent with Potent but Selective Cytotoxic Activity against Cancer", JOURNAL OF MEDICINAL CHEMISTRY, vol. 48(13), JPN6019049182, 2005, pages 4474 - 4481, ISSN: 0004262427
MARKOVITS, JUDITH; WILMANSKA, DOROTA; LESCOT, ELIE; STUDZIAN, KAZIMIERZ; SZMIGIERO, LESZEK; GNIAZDOW: "DNA binding, cytotoxicity and inhibitory effect on RNA synthesis of two new 1-nitro-9-aminoacridine", CHEMICO-BIOLOGICAL INTERACTIONS, vol. 70(1-2), JPN6019049184, 1989, pages 73 - 87, ISSN: 0004262428
CANCER REPORTS, vol. 1(1), JPN7020001236, 2011, pages 1 - 8, ISSN: 0004262429
CANCERS, vol. 3(1), JPN7020001238, 2011, pages 1 - 16, ISSN: 0004262430
PLOS ONE, vol. 7(6), JPN7020001239, 2012, pages 37841 - 1, ISSN: 0004262431
ZHOU, ZHIGANG; LI, YUMIN: "Molecular dynamics simulation of S100B protein to explore ligand blockage of the interaction with p5", JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, vol. 23(10), JPN6019049187, 2009, pages 705 - 714, ISSN: 0004174259
BRANA, MIGUEL F.; CASARRUBIOS, LUIS; DOMINGUEZ, GEMA; FERNANDEZ, CARLOS; PEREZ, JOSE M.; QUIROGA, AD: "Synthesis, cytotoxic activities and proposed mode of binding of a series of bis{[(9-oxo-9,10-dihydro", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 37(4), JPN6019049188, 2002, pages 301 - 313, ISSN: 0004174260
HARIPRAKASHA, HUMCHA K.; KOSAKOWSKA-CHOLODY, TERESA; MEYER, COLIN; CHOLODY, WIESLAW M.; STINSON, SHE: "Optimization of Naphthalimide-imidazoacridone with Potent Antitumor Activity Leading to Clinical Can", JOURNAL OF MEDICINAL CHEMISTRY, vol. 50(23), JPN6019049186, 2007, pages 5557 - 5560, ISSN: 0004174258
MARKOVITS, JUDITH; WILMANSKA, DOROTA; LESCOT, ELIE; STUDZIAN, KAZIMIERZ; SZMIGIERO, LESZEK; GNIAZDOW: "DNA binding, cytotoxicity and inhibitory effect on RNA synthesis of two new 1-nitro-9-aminoacridine", CHEMICO-BIOLOGICAL INTERACTIONS, vol. 70(1-2), JPN6019049184, 1989, pages 73 - 87, ISSN: 0004262428
CANCER REPORTS, vol. 1(1), JPN7020001236, 2011, pages 1 - 8, ISSN: 0004262429
CANCERS, vol. 3(1), JPN7020001238, 2011, pages 1 - 16, ISSN: 0004262430
PLOS ONE, vol. 7(6), JPN7020001239, 2012, pages 37841 - 1, ISSN: 0004262431
ZHOU, ZHIGANG; LI, YUMIN: "Molecular dynamics simulation of S100B protein to explore ligand blockage of the interaction with p5", JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, vol. 23(10), JPN6019049187, 2009, pages 705 - 714, ISSN: 0004174259
BRANA, MIGUEL F.; CASARRUBIOS, LUIS; DOMINGUEZ, GEMA; FERNANDEZ, CARLOS; PEREZ, JOSE M.; QUIROGA, AD: "Synthesis, cytotoxic activities and proposed mode of binding of a series of bis{[(9-oxo-9,10-dihydro", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 37(4), JPN6019049188, 2002, pages 301 - 313, ISSN: 0004174260
HARIPRAKASHA, HUMCHA K.; KOSAKOWSKA-CHOLODY, TERESA; MEYER, COLIN; CHOLODY, WIESLAW M.; STINSON, SHE: "Optimization of Naphthalimide-imidazoacridone with Potent Antitumor Activity Leading to Clinical Can", JOURNAL OF MEDICINAL CHEMISTRY, vol. 50(23), JPN6019049186, 2007, pages 5557 - 5560, ISSN: 0004174258
Attorney, Agent or Firm:
Masutani Takeshi
Hiroyuki Nakao
Hiroyuki Nakao