Title:
ＩＲＡＫ阻害剤としてのヘテロアリール化合物及びその使用
Document Type and Number:
Japanese Patent JP2018531920
Kind Code:
A
Abstract:
本発明はIRAK阻害剤として有用である式（I）の化合物及びその医薬上許容される組成物に関する。
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Inventors:
Catherine Jolan-Le Blanc
Luokushi Ran
Austin Chen
Ryan C. Clark
Luokushi Ran
Austin Chen
Ryan C. Clark
Application Number:
JP2018513803A
Publication Date:
November 01, 2018
Filing Date:
September 16, 2016
Export Citation:
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
International Classes:
C07D401/04; A61K31/4196; A61K31/422; A61K31/4439; A61K31/497; A61K31/4995; A61K31/501; A61K31/506; A61K31/5355; A61K31/5377; A61K31/5386; A61K31/541; A61K31/551; A61K31/553; A61P1/04; A61P3/10; A61P9/00; A61P9/10; A61P13/10; A61P13/12; A61P17/06; A61P19/02; A61P19/10; A61P25/00; A61P25/16; A61P25/28; A61P31/04; A61P35/00; A61P37/02; A61P43/00; C07D403/04; C07D413/04; C07D413/14; C07D417/04; C07D417/14; C07D471/18; C07D487/18; C07D498/18
Domestic Patent References:
| JP2005532251A | 2005-10-27 | |||
| JP2014533286A | 2014-12-11 | |||
| JP2013532726A | 2013-08-19 | |||
| JP2012046541A | 2012-03-08 | |||
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Foreign References:
| WO2005079791A1 | 2005-09-01 | |||
| WO2010126922A1 | 2010-11-04 | |||
| WO2014121931A1 | 2014-08-14 |
Other References:
DATABASE REGISTRY [ONLINE] CHEMICAL ABSTRACT SERVICE, US, JPN7020002816, 4 December 2011 (2011-12-04), ISSN: 0004343622
DE NANTEUIL, GUILLAUME; PORTEVIN, BERNARD; FRADIN, ARMEL; BONNET, JACQUELINE: "5-imidazol-1-yl-1H-benzimidazoles as Interleukin-1 inhibitors: a key approach in the search of new t", ACTUALITE CHIMIQUE, JPN6020034353, 2000, pages 48 - 54, ISSN: 0004343623
BUCKLEY G M.,ET.AL.: "IRAK-4 inhibitors. Part III : A series of imidazo[1,2-a]pyridines", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18(12), JPN6020034355, 2008, pages 3656 - 3660, ISSN: 0004343624
DE NANTEUIL, GUILLAUME; PORTEVIN, BERNARD; FRADIN, ARMEL; BONNET, JACQUELINE: "5-imidazol-1-yl-1H-benzimidazoles as Interleukin-1 inhibitors: a key approach in the search of new t", ACTUALITE CHIMIQUE, JPN6020034353, 2000, pages 48 - 54, ISSN: 0004343623
BUCKLEY G M.,ET.AL.: "IRAK-4 inhibitors. Part III : A series of imidazo[1,2-a]pyridines", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18(12), JPN6020034355, 2008, pages 3656 - 3660, ISSN: 0004343624
Attorney, Agent or Firm:
Atsushi Aoki
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Takahide Sasaki
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Takahide Sasaki